Prostate Cancer
Conditions
Brief summary
Volume controlled ventilation(VCV) is a most common used ventilation mode during general anesthesia. But VCV can cause high airway peak pressure when patient under steep Trendelenberg position with pneumoperitoneum. Autoflow-VCV can reduce airway peak pressure and improve dynamic compliance. We will compare parameters(arterial blood gas analysis, airway compliance, etc) when each group applied VCV and autoflow-VCV during RALP.
Detailed description
Robot assisted laparoscopic radical prostatectomy(RALP) has been used to treatment of prostate cancer since 2001. RALP offers some advantage such as reduced blood loss, sparing nerves, less postoperative pain. However, RALP require steep Trendelenberg position with pneumoperitoneum. It can cause increased airway peak pressure and unwanted hemodynamic effect under conventional volume controlled ventilation(VCV). Autoflow-VCV use decelerating flow, can reduce airway peak pressure and improve dynamic compliance. We will compare parameters(arterial blood gas analysis, airway compliance, etc) when each group applied VCV and autoflow-VCV during RALP.
Interventions
After induction of anesthesia and intubation, patients will be applied VCV by Zeus®(Dräger, Germany). \- Tidal volume : 8ml/kg(ieal body weight), inspiration:expiration ratio = 1:2, FiO2 = 0.5, fresh gas flow = 3L/min respiratory rate(RR) : 12/min. After position, RR can changed 2 times each per 5 minutes to maintain end tidal CO2 around 35. Positive end expiratory pressure will not used.
After induction of anesthesia and intubation, patients will be applied autoflow- VCV by Zeus®(Dräger, Germany). \- Tidal volume : 8ml/kg(ideal body weight), inspiration:expiration ratio = 1:2, FiO2 = 0.5, fresh gas flow = 3L/min respiratory rate(RR) : 12/min. After position, RR can changed 2 times each per 5 minutes to maintain end tidal CO2 around 35. Positive end expiratory pressure will not used.
Sponsors
Korea University Anam Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
19 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Adult (age 19-65) * American Society of Anesthesiology Classification I-III
Exclusion criteria
* cardiovascular disease, cerebrovascular disease, pulmonary disease * over BMI 30
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Airway pressure | 4hours | Airway pressure will be measured under specified ventilation mode. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Vital sign | 4hours | Vital sign will be measured under specified ventilation mode. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Arterial blood gas analysis | 4hours | Arterial blood gas analysis will be measured under specified ventilation mode. |
Outcome results
None listed