Diabetes
Conditions
Keywords
Dexmedetomidine, Diabetic, glycometabolism, sedation
Brief summary
Dexmedetomidine's Sedative Effect on Diabetic Patient
Detailed description
Dexmedetomidine is a high selective α2 agonist,its sedative and analgesia feature is acclaimed. The pathogenesis of type 2 diabetes mellitus is associated with α2 excessive adrenaline receptors expression. This study is to evaluate whether the use of dexmedetomidine is helpful to Diabetic Patient through its antisympathetic effect
Interventions
DRUGDexmedetomidine
During anesthesia induction, all patients will be given propofol,fentanyl,vecuronium bromide.But before induction start in Dexmedetomidine(D) group, patient will be given dexmedetomidine 1μg/Kg for 10 minutes In anesthesia maintenance, D group will be given dexmedetomidine 0.4μg/Kg.h until 40 minutes before the end of surgery
DRUGplacebo
During anesthesia induction, all patients will be given propofol,fentanyl,vecuronium bromide.But before induction start in Placebo(P) group, patient will be given placebo for 10 minutes In anesthesia maintenance, D group will be given placebo until 40 minutes before the end of surgery
Sponsors
Shaanxi Provincial People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
40 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Age between 40 and 60 * Selective epigastrium surgery * In
Exclusion criteria
* American Society of Anesthesiology (ASA) Physical Status\>3 * Duration of operation \>3 hours * Hypovolemia,sinus bradycardia,atrioventricular block,severe hepatic and renal dysfunction,severe cardiac insufficiency
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sedation level | from 5 minutes before medication to 10 minutes after Dexmedetomidine discontinuance，length of time frame is about 2 hours | Ramsay score and BIS will be recorded before medication,5 min after medication, medication ending, 5 and 10 min after medication |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mean arterial pressure | participants will be followed from operation day to first postoperative day，an expected average of 2 days | 10 min after medication, before intubation, after intubation, after skin incision,60 minutes after skin incision, after extubation,first day after operation |
| blood glucose measured by Biochemical test | participants will be followed from operation day to first postoperative day，an expected average of 2 days | it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation |
| cortisol measured by Biochemical test | participants will be followed from operation day to first postoperative day，an expected average of 2 days | it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation |
| Heart rate | participants will be followed from operation day to first postoperative day，an expected average of 2 days | recorded at before medication,5 min after medication, medication ending, 5 and 10 min after medication, before intubation, after intubation, after skin incision,60 minutes after skin incision, after extubation,first day after operation |
| adrenaline measured by Biochemical test | participants will be followed from operation day to first postoperative day，an expected average of 2 days | it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation |
| noradrenaline measured by Biochemical test | participants will be followed from operation day to first postoperative day，an expected average of 2 days | it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation |
| insulin measured by Biochemical test | participants will be followed from operation day to first postoperative day，an expected average of 2 days | it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation |
Contacts
Primary ContactYulong Song
Outcome results
None listed