ARDS
Conditions
Keywords
Critical Care, ARDS, Intrapulmonary Percussive Ventilation, VDR4, Lung aeration, CT scan
Brief summary
The study is intended to elucidate the pulmonary effects of Intrapulmonary Percussive Ventilation (IPV) with VDR4 ventilator of patients with ARDS, using computed tomography (CT).
Detailed description
Prospective clinical study in ICU of ventilated patients with ARDS. The morphologic pulmonary effects of IPV with VDR4 are not known to the investigators' knowledge. The main aim is to quantify recruited, normally aerated and overinflated parts of the lungs after a 1 hour treatment with IPV. Patients with ARDS (focal and non focal) consecutively admitted to the investigators' ICU are enrolled after informed consent. Patients are intubated and ventilated with Servo-I (GE) and ventilation is optimized according to ARDS-network recommandations. A first thoracic CT-scan is performed with ICU ventilator and then the patient is ventilated with VDR4 during 1 hour. A second thoracic CT-scan is then performed and the patient re-ventilated with ICU ventilator. Arterial blood gases and hemodynamic parameters are recorded during experiments. CT-scan are analysed and compared for normally aerated, overinflated and recruited lung parenchyma. Regions are determined thanks to their Hounsfield units (HU).
Interventions
DEVICEServo-i
DEVICE- Intubation
DEVICEVentilation ( with an ICU conventional ventilator)
DEVICEVDR4 ventilator (Intrapulmonary Percussive Ventilation)
DEVICECT scan
Sponsors
University Hospital, Estaing
University Hospital, Clermont-Ferrand
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Patients ventilated more than 48 h * Sedated patients * ARDS moderate or severe (Berlin 2012) * Patients who have given their consent or his family * Patients aged between 18 and 85 years
Exclusion criteria
* Pregnant ou lactating women * Hemodynamic instability * Chronic respiratory insufficiency. * Pneumothorax * Fistulae bronchopleural
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline (H0) in volume of overinflated lung at H1 | at Hour 0(just before Intrapulmonary Percussive Ventilation) and Hour 1(just after Intrapulmonary Percussive Ventilation) |
Secondary
| Measure | Time frame |
|---|---|
| Volume of recruited lung | at day 1 (between H0 and H1) |
| Heart rate | at day 1 ((every 10 min between H0 and H1) |
| Volume of normally aerated lung | at Hour 0 (just before Intrapulmonary Percussive Ventilation ) and Hour 1 (just after Intrapulmonary Percussive Ventilation) |
| Arterial blood gaz | at day 1 ((every 10 min between H0 and H1) |
| Evolution of catecholamine doses (µg/Kg/min) | at day 1 (every 10 min between H0 and H1) |
| Blood pressure | at day 1 (every 10 min between H0 and H1) |
Countries
France
Contacts
Primary ContactPatrick LACARIN
Outcome results
None listed