Normobaric Hypoxic Training and Multiple Sclerosis

Cardiorespiratory, Metabolic and Immunoregulatory Response to Hypoxia in Multiple Sclerosis Patients: A Pilot Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02509897

Acronym

MS_EPOXI

Enrollment

Registered

2015-07-28

Start date

2015-07-31

Completion date

2018-07-31

Last updated

2022-07-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis

Keywords

Hypoxia training, Activity energy expenditure, Immunoregulation, Energy Metabolism, Exercise

Brief summary

To study the effects of normobaric hypoxic training on cardiorespiratory fitness, resting, postprandial and exercise activity energy expenditure, immunoregulatory functions and serum erythropoietin levels in relapsing-remitting multiple sclerosis patients.

Interventions

OTHERHypoxic training

Hypoxic training 3 times per week four four weeks

OTHERNormoxic training

Normoxic training 3 times per week four four weeks

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

* stable immunomodulatory therapy * expanded disability status scale score \< 4.5 * body mass index 18.5 - 29.9 kg/m2

Exclusion criteria

* clinically relevant heart, lung, liver, and kidney diseases

Design outcomes

Primary

Measure	Time frame
Activity energy expenditure measured by indirect calorimetry (respiratory chamber)	Change from baseline at 4 weeks

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 23, 2026