Inflammation, Sepsis, Trauma
Conditions
Keywords
Transcriptome profiling
Brief summary
Discovery of differences in the host response in patients with systemic inflammation and sepsis, and identification of novel, specific markers by using a longitudinal clinico-transcriptomic approach.
Detailed description
The aim of this study is to link defined clinical phenotypes with data on RNA obtained from blood samples by high throughput technologies. Genetic and molecular characteristics of the immune system after severe trauma will be crosslinked to clinical aspects of posttraumatic organ failure, with the goal of identifying typical molecular fingerprints. Patients with and without sepsis or organ failure will be compared with the goal to develop a diagnostic test designed to predict the clinical course following severe trauma. Criteria for study enrollment includes patient age ≥18 y, an Injury Severity Score (ISS) ≥ 17 points, and time from injury to admission \< 6 h. Whole blood from trauma patients will be collected within the first 6 h after trauma (day 0) and on days 1, 2, 3, 5, 7, 10, 14, and 21.
Interventions
None listed
Sponsors
University of Zurich
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patient age ≥18 y * Injury Severity Score (ISS) ≥ 17 points * time from injury to admission \< 6 h.
Exclusion criteria
Moribund Patients with: * PH \< 7,1 or * Lactate \> 15 mmol/l or * Base deficit \> 15 mEq/l
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systemic Inflammation and Sepsis | 21 days after trauma |
Secondary
| Measure | Time frame |
|---|---|
| Mortality | 28 days after Trauma |
| Nosocomial infections | 21 days after trauma |
| SOFA score | 21 days after trauma |
| Systemic inflammation score | 21 days after trauma |
| Hospital length of stay | 28 days after trauma |
| ICU length of stay | 28 days after trauma |
Countries
Switzerland
Outcome results
None listed