Short-term Effects of Oxytocin Nasal Spray on Chronic Tinnitus

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02508220

Enrollment

Registered

2015-07-24

Start date

2015-07-31

Completion date

2015-11-30

Last updated

2015-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Tinnitus

Brief summary

The study compares the short-term tinnitus reduction following a single oxytocin intervention with a placebo control condition.

Interventions

DRUGSyntocinon

Oxytocin nasal spray

DRUGPlacebo

distilled water in nasal spray

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* chronic tinnitus with a duration \> 6 months * medical examination by an ENT specialist * sufficient knowledge of the Portuguese language to follow the instructions and answer the questionnaires * VAS score \>4 points

Exclusion criteria

* vascular tinnitus * muscular tinnitus * conductive hearing loss * previous experience with oxytocin nasal spray * additional medications during the intervention

Design outcomes

Primary

Measure	Time frame
Change of Clinical global impression scale	30 minutes after intervention
Change of tinnitus on VAS	30 minutes after intervention

Secondary

Measure	Time frame	Description
Audiometry measured in dB HL	within one hour before intervention	measured in dB HL
Minimum Masking Level measured in dB HL	within one hour before intervention	measured in dB HL
Tinnitus Matching	within one hour before intervention	Frequency measured in Hz

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026