Growth Hormone Deficiency
Conditions
Keywords
GHD
Brief summary
The aim of this study is to assess the developmental patterns of lung function in children affected by growth hormone deficiency after one year of GH therapy.The assessment by specific questionnaires of quality of life and of parental stress index.Parameters will be evaluated at the time of the diagnosis and after 12 months of GH therapy.
Detailed description
Observational longitudinal study in children affected by idiopathic growth hormone deficiency (GHD): lung function parameters assessment; quality of life assessment; stress parenting assessment (Pneumo GHD). The aim of this study is to assess the developmental patterns of lung function in children affected by growth hormone deficiency after one year of GH therapy.The assessment by specific questionnaires of quality of life and of parental stress index.Parameters will be evaluated at the time of the diagnosis and after 12 months of GH therapy.
Interventions
From Baseline Visit (T0) to 6th Month Visit 0,025 mg/kg Growth Hormone/die. From 6th Month Visit to 12th Month Visit 0,030 mg/Kg Growth Hormone/die.
Sponsors
Stefania La Grutta, MD
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 15 Years
Healthy volunteers
No
Inclusion criteria
* GH deficiency
Exclusion criteria
* Respiratory infections 4 weeks before the recruitment * Children with autoimmune diseases * Therapy with drugs able to modify the lung function
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of the developmental patterns of lung function before and after GH by spirometry | 1 year | Assessment of lung function before and after administration of GH in children with growth hormone deficiency by spirometry |
Outcome results
None listed