Diabetes Mellitus
Conditions
Keywords
Blood glucose, Humans, Postprandial, Sugar, Carbohydrate, Oat beta-glucan
Brief summary
The purpose of this study was to determine the impact of serving size and the addition of sugar on the glycemic response elicited by oatmeal compared to that elicited by cream of rice cereal.
Interventions
OTHERClassic Quaker Quick Oats
Various doses of oats without or with sugar
OTHERCream of Rice Cereal
Various doses of cereal without sugar
Sponsors
PepsiCo Global R&D
Applied Statistics and Consulting
Glycemic Index Laboratories, Inc
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* body mass index (BMI) 20.0 - 34.9 kg/m²
Exclusion criteria
* known to have diabetes * use of medications considered by the principal investigator to influence glycemic responses
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incremental area under the blood glucose response curve | For 2 hours after consuming each test meal |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time to peak | During 2 hour period after consuming each test meal | The time at which the peak rise of blood glucose occured. |
| Peak rise of blood glucose | During 2 hour period after consuming each test meal | The highest concentration of blood glucose achieved after eating minus the fasting blood glucose. |
| Mean rate of decline in blood glucose | During 2 hour period after consuming each test meal | The rate of change in blood glucose between consecutive time points (Tx and T(x+1)) was calculated as: Rx = (Gx G(x+1))/(Tx-T(x+1)), where G(x+1) and Gx were the glucose concentrations at times T(x+1) and Tx, respectively. The mean rate of decline in blood glucose (Mean RD) was calculated as the weighted average of all the Rx values from the time of the peak glucose concentration to 120 min, with the weight based on the length of the time interval. |
| Maximum rate of decline in blood glucose | During 2 hour period after consuming each test meal | The rate of change in blood glucose between consecutive time points (Tx and T(x+1)) was calculated as: Rx = (Gx G(x+1))/(Tx-T(x+1)), where G(x+1) and Gx were the glucose concentrations at times T(x+1) and Tx, respectively. . The maximum rate in blood glucose decline (Max RD) was calculated as the maximum of all the Rx values from the time of the peak glucose concentration to 120 min. |
| Time to baseline | During 2 hour period after consuming each test meal | The time for blood glucose to return to baseline was linearly interpolated between the first blood glucose concentration below fasting and the previous value; if blood glucose did not reach baseline, Bt was taken to be 120min. |
Countries
Canada
Outcome results
None listed