Juvenile Idiopathic Arthritis, Septic Arthritis
Conditions
Keywords
Arthritis, septic, Juvenile idiopathic arthritis, diagnosis, proteomic, cytokine, monocytes
Brief summary
The aim of this study is to find markers that could differentiate infectious and inflammatory arthritis. The investigators want to find markers by differential analysis by compare synovial fluids of septic and inflammatory arthritis. The investigators will use for this analysis, proteomics, cytokine dosage and monocyte typing by flow cytometry analysis. The investigators will use one marker or a score with biological and clinical data to discriminate arthritis of infectious and inflammatory etiology.
Interventions
PROCEDUREArticular punction, salivary samples, blood sample
Sponsors
University Hospital, Montpellier
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
6 Months to 18 Years
Healthy volunteers
No
Inclusion criteria
* Septic arthritis with bacteriological identification * Juvenile idiopathic arthritis beyond the ILAR definition * Having acute arthritis requiring an articular draining * Child benefiting from a national insurance scheme * Collection of the consent of the parents or the legal representative
Exclusion criteria
* Contraindication in an articular draining: platelet 50 000 / mm3, Rate of prothrombins lower than 70 %, activated partial thromboplastin times (APTT)\> 1,5 * Treatment by biotherapy, corticoids or other immuno suppressor in the month preceding the articular draining. * Treatment by antibiotic begun more than 24 hours before the draining.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Qualitative analysis of new biological markers (proteic, cytokine or cellular) that discriminate inflammatory and infectious arthritis. | 1 day | Identify blood sampling biomarkers of Arthritis childhood |
Countries
France
Outcome results
None listed