Nasopharyngeal Carcinoma
Conditions
Keywords
Vestibular function, chemoradiotherapy
Brief summary
Nasopharyngeal carcinoma (NPC) is usually treated with chemoradiotherapy. While the effects of this treatment on cochlear function is well characterized, its effect on vestibular function is not well studied. In this study the investigators will study the vestibular function of 50 patients undergoing chemoradiotherapy for NPC both before and after treatment in order to better define its effects. All patients will undergo a validated questionnaire (dizziness handicap index), posturography, audiometry and vestibular-evoked myogenic potentials.
Interventions
RADIATIONChemoradiotherapy for nasopharyngeal carcinoma
Note that this is standard care for NPC and patients are not assigned to different intervention groups. All patients in the study will receive the same treatment (chemoradiotherapy) and will be observed for changes in vestibular function.
Sponsors
Rabin Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 18 years or older. * Biopsy-proven NPC. * About to undergo chemoradiotherapy with intensity-modulated radiotherapy (IMRT).
Exclusion criteria
* Pregnancy. * Prior vestibular dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective dizziness and vestibular dysfunction using the dizziness handicap index | 6 months after completion of treatment |
| Hearing level using standard audiometry | 6 months after completion of treatment |
| Objective vestibular function using posturography | 6 months after completion of treatment |
| Vestibular saccular function using vestibular-evoked myogenic potentials | 6 months after completion of treatment |
Countries
Israel
Contacts
Primary ContactYotam Shkedy, MD
Outcome results
None listed