Healthy
Conditions
Brief summary
Maintaining muscle mass and function is important in healthy ageing to maintain quality of life. Loss of muscle mass is major problem, as beyond the age \ 50, muscle mass declines by \ 1-2% a year. To prevent this loss, the investigators need to understand the mechanism regulating muscle mass as we age. In this project the investigators aim to determine these mechanisms using a new technique of heavy water ingestion, this allows measurement of multiple aspects of skeletal muscle mass metabolism e.g. protein synthesis, over long periods (6 weeks) as people go about their normal everyday activities. The investigators also aim to determine the influence of resistance exercise training on older muscle, as well as differences between men and women in muscle responses to exercise and nutrition HMB (beta-hydroxy-beta-methylbutyrate).
Interventions
BEHAVIORALExercise
Sponsors
The Dunhill Medical Trust
University of Nottingham
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Young (18-30y) and old (60-75y) individuals who are generally healthy and recreationally active
Exclusion criteria
* Active cardiovascular disease * Cerebrovascular disease including previous stroke, aneurysm (large vessel or intracranial) * Respiratory disease including pulmonary hypertension or Chronic obstructive pulmonary disease, Hyper/ hypo parathyroidism, hyper/ hypothyroidism, * Cushing's disease, diabetes * Active inflammatory bowel disease * Renal disease * Malignancy * Recent steroid treatment (within 6 mo), or hormone replacement therapy Clotting dysfunction * Musculoskeletal or neurological disorders * Any disease requiring long-term drug prescriptions, including statins
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle Protein Synthesis | 0-6 Weeks | Comparison of muscle protein synthesis between young and older individuals and in response to 6 weeks unilateral exercise training and supplementation |
| Muscle Strength | 0-6 Weeks | Maximal voluntary contractions of the quadriceps will be performed (leg extension) in the trained and untrained legs. This will be performed at baseline and repeated throughout to monitor training progression |
Countries
United Kingdom
Contacts
Primary ContactKen Smith, PhD
Backup ContactMatthew Brook
Outcome results
None listed