Newborn Cleft Lip and Slot Carrier
Conditions
Brief summary
We seek to compare biochemically and histologically the nasal cartilage and ear in the newborn cleft lip and slot carrier in order to improve the quality of care and patient comfort after surgery of cheilorhinoplasty which is the primary treatment slots . The concentration of hyaluronic acid as well as in type 1 collagen and 3 are assayed by immunohistochemistry and study of mRNA and then they are compared according to the type of cartilage. This comparison is done on nasal cartilage samples and atrial newborns holders of cleft lip and operated in the neonatal period. Given the difficulty and constraint of time it takes to reach the 20 subjects of our study , we will also add to our population the stillborn babies before 25SA and newborns who die before the age of 28 days and having had an autopsy.
Interventions
OTHERMeasurements of concentration of hyaluronic acid as well as in type 1 collagen and 3
Sponsors
University Hospital, Caen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 28 Days
Healthy volunteers
No
Inclusion criteria
* Infants aged 0 to 5 weeks with an isolated cleft lip and palate, that is to say non-syndromic, and that will be operated for cheilorhinoplasty neonatal, whose parents have read and understood the document Information and accepted and signed informed consent, * Children born without life before 25SA and whose parents have read and understood the Information and accepted and signed informed consent for diagnostic purposes permission to autopsy and scientific purposes and / or therapeutic. * Newborns who died before 28 days of life and whose parents have read and understood the Information and accepted and signed informed consent for diagnostic purposes permission to autopsy and scientific purposes and / or therapeutic. * Patients And relatives of patients who received clear information and having signed an informed consent, * Patients Benefiting from a health insurance plan
Exclusion criteria
* Patient with no lip slots ( bike palate only or other Tessier slot ) ) * Patient having slots syndromic cleft lip * Patient whose parents refuse entry into the study. * Children born without life before 25SA * Newborns who died after 28 days of life
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurements of concentration of hyaluronic acid as well as in type 1 collagen and 3 | Baseline |
Countries
France
Outcome results
None listed