Acute Myocardial Infarction, Ischemic Cardiomyopathy, Myocardial Infarction
Conditions
Brief summary
The purpose of the present study is to evaluate the efficacy of the preconditioned autologous bone marrow mesenchymal stem cells for patients with ischemic heart diseases.
Interventions
BIOLOGICALBMMSCs
Sponsors
Sun Yat-sen University
Academy Military Medical Science, China
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
No minimum to 75 Years
Healthy volunteers
No
Inclusion criteria
* Age under 75; * Clinical diagnosis of acute Myocardial Infarction, chronic Myocardial Infarction and Ischemic Cardiomyopathy * NYHA (New York Heart Association) grade: III-IV, LVEF (left ventricular ejection fraction): 25-50%; * No infection diseases including HBV (hepatitis B virus), HCV (hepatitis C virus ), syphilis and AIDS; * No psychiatric illnesses and speaking dysfunction; * Informed consent.
Exclusion criteria
* More than 75 years old; * LVEF\<24%; * Unstable hemodynamics, shock; * Severe infection; * Patients have tumor or other lethal diseases (expectation of life\<6 months); * Radiation patients; * hematopoietic malignancy including Haemophiliacs; * Anemia (Hb\<100g/L); * The other clinical trial participants within one month; * Abnormal increasing of the blood biochemical indicators that is not explained by the conditions; * Informed refusal.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LVEF (left ventricular ejection fraction) | one year |
Contacts
Primary ContactXuetao Pei, M.D., Ph.D
Backup ContactJunnian Zhou, Ph.D
Outcome results
None listed