Atrial Fibrillation
Conditions
Brief summary
This study is to evaluated the interruption schedule of NOAC in patients who undergo atrial fibrillation ablation. The investigators will compare the bleeding complications were classified as major and minor bleeding, thromboembolic, vascular complications, Re-admission and increased in the length of hospital stay during the 30-day post-radiofrequency catheter ablation(RFCA) period among patients who interrupt NOAc 24hours before ablation and patients who stop NOAC in the morning of the procedure.
Interventions
DRUGnovel oral anticoagulant for 30 days
novel oral anticoagulant includes 'dabigatran,Pradaxa®', 'rivaroxaban,Xarelto®', and 'apixaban, Eliquis®'.
DRUGnovel oral anticoagulant for 24 hour
novel oral anticoagulant includes 'dabigatran,Pradaxa®', 'rivaroxaban,Xarelto®', and 'apixaban, Eliquis®'.
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients who consent with study 2. Patients with Atrial fibrillation (20-80 years old) 3. patients who undergoing catheter ablation of atrial fibrillation due to symptomatic, drug refractory atrial fibrillation 4. Patients possible to NOAC
Exclusion criteria
1. Patients who do not agree with study inclusion 2. eGRF \< 30ml/min 3. Impossible to NOAC 4. Structural cardiac disease 5. Major hemorrhagic complication 6. CHA2DS2-VASc score \> 5 7. Patients who have experienced Ischemic cerebellar infarction more than 2times
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence of major bleeding complications | during 30 days post-AF ablation. | Bleeding complication is assessed by physical examination or laboratory measurement |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| incidence of thromboembolism | during 30 days post-AF ablation. | thromboembolism is diagnosed by both clinical situations and image studies combined. |
| incidence of minor bleeding | during 30 days post-AF ablation. | — |
| Re-admission rate related procedure | during 30 days post-AF ablation. | — |
| length of hospital stay | during 30 days post-AF ablation. | — |
| incidence of vascular complications | during 30 days post-AF ablation. | vascular complication is diagnosed by both clinical situations and image studies combined. |
Countries
South Korea
Outcome results
None listed