Pregnancy
Conditions
Brief summary
This study aimed to investigate whether there are measurable differences in CHANS function in pregnant women who receive only standard antenatal care compared with those who additionally undertake a programme of regular physical exercise.
Detailed description
The health benefits of physical exercise in the non-pregnant population are generally appreciated but its influence during pregnancy has not been clearly demonstrated. The focus of this proposal is to obtain for the first time a comprehensive understanding of the influence of regular physical exercise during pregnancy on cardiovascular, haemodynamic and autonomic nervous system (CHANS) parameters during pregnancy and following childbirth. This will involve assessing heart rate variability and cardiac stroke volume. This study will allow the investigators to compare CHANS parameters in pregnant women who are randomly assigned into three groups: a 'standard care' group and two groups who engage in a supervised programme of physical exercise (either land-based or water-based). The investigators will assess CHANS parameters at three stages during pregnancy and on one occasion following childbirth. This will allow the influence of regular (weekly) physical exercise on CHANS physiology to be assessed during advancing gestation. The investigators will thus use this study to provide initial evidence of the health benefits of regular and specific forms of antenatal physical exercise.
Interventions
BEHAVIORALPhysical Exercise Participation
Sponsors
Swansea University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Eligible participants were apparently healthy pregnant women aged 18 years or over, with no existing complications of pregnancy at their 12-week dating scan.
Exclusion criteria
*
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Heart Rate Variability - Time Point 1 | 10-12 weeks gestation | Determined from 3-lead ECG, assessed as absolute value |
| Heart Rate Variability - Time Point 2 | 24-28 weeks gestation | Determined from 3-lead ECG, assessed as absolute value |
| Heart Rate Variability - Time Point 3 | 34-36 weeks gestation | Determined from 3-lead ECG, assessed as absolute value |
| Heart Rate Variability - Time Point 4 | 12 weeks post-birth | Determined from 3-lead ECG, assessed as absolute value |
| Cardiac Stroke Volume - Time Point 1 | 10-12 weeks gestation | Determined from thoracic impedance cardiogram, assessed as absolute value |
| Cardiac Stroke Volume - Time Point 2 | 24-28 weeks gestation | Determined from thoracic impedance cardiogram, assessed as absolute value |
| Cardiac Stroke Volume - Time Point 3 | 34-36 weeks gestation | Determined from thoracic impedance cardiogram, assessed as absolute value |
| Cardiac Stroke Volume - Time Point 4 | 12 weeks post-birth | Determined from thoracic impedance cardiogram, assessed as absolute value |
Outcome results
None listed