Depression
Conditions
Brief summary
A randomized controlled trial comparing wake therapy (single night) followed by bright light therapy to treatment as usual.
Interventions
BEHAVIORALSingle night's wake therapy
Eligible patients are assisted in maintaining total sleep deprivation during one night
DEVICEBright light
Bright light according to patients´ own circadian rhythm each morning for a week.
OTHERTreatment as usual - inpatient care
All patients are admitted due to severe depression and are under observation and most receive antidepressive medication and if necessary anxiolytic/antipsychotic medication.
OTHERInformative meeting
A short sleep hygiene consultation.
DRUGTreatment as usual - medicine
Since all patients are admitted due to a severe mental illness, they will receive medication according to indication. Most patients have already tried more than one antidepressant at the time of admission. In cases of severe anxiety, anxiolytics are prescribed but this is kept to a minimum.
Sponsors
Sahlgrenska University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Depressive episode requiring admission to a psychiatric hospital (including unipolar and bipolar depression).
Exclusion criteria
* Psychotic symptoms/agitation * Compulsory admission * Confusion * Active substance use disorder * Eye disease preventing bright light therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MADRS-S score reduction of 50% | One week | Montgomery Asberg Depression Rating Scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Re-admission | 10-14 weeks | — |
| CGI score | One week | Clinical global impression |
| MADRS-S score at discharge | Participants will be followed at discharge, an expected average of 2-3 weeks | Montgomery Asberg Depression Rating Scale |
| MADRS-S score at follow-up | 10-14 weeks | Montgomery Asberg Depression Rating Scale |
| Length of stay | The number of days between admission and discharge | Patients will be followed up 10-14 weeks after discharge and the total number of days in inpatient services calculated. |
| ISI score score at follow-up | 10-14 weeks | Insomnia Severity Index - Self administered scale of sleep quality |
| ISI score reduction of 50% | One week | Insomnia Severity Index - Self administered scale of sleep quality |
| Medication use | 10-14 weeks | The use of antidepressants, anxiolytics or other psychiatric medication will be registered at follow-up. The number of patients using more than one medication and the dosage will be compared. |
| ISI score score at discharge | Participants will be followed at discharge, an expected average of 2-3 weeks | Insomnia Severity Index - Self administered scale of sleep quality |
Countries
Sweden
Outcome results
None listed