Using Multimodal Prehabilitation to Improve Outcomes for Frail Patients Undergoing Resection of Colorectal Cancer

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02502760

Enrollment

120

Registered

2015-07-20

Start date

2015-08-31

Completion date

2019-06-19

Last updated

2019-08-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Neoplasms

Keywords

Postoperative Complications, Perioperative Care, Colorectal Surgery, Frail Elderly

Brief summary

The purpose of this study is to determine if a program of physical activity, nutritional supplements and relaxation techniques is effective at decreasing post operative complications in frail colorectal cancer patients undergoing resection.

Interventions

BEHAVIORALPhysical Exercise Program

Physical exercises personalized by a kinesiologist consisting of walking or stationary bike and elastic band exercises.

DIETARY_SUPPLEMENTWhey Protein Isolate Powder

Nutritional counselling is given to patients to ensure their daily proteins and energy requirements are met. Whey Protein Isolate Powder (Immunocal) is provided. Immunocal1.5g/kg PO (by mouth) per day separated in 2 daily doses

BEHAVIORALRelaxation Techniques

Relaxation techniques consisting of breathing exercises and using a relaxation CD.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Colorectal cancer patient undergoing resection * Frail or intermediately frail patients (Fried score 2 and above)

Exclusion criteria

* Unable to communicate in French or English * Premorbid conditions contraindicating physical exercise (dementia, Parkinson Disease, previous stroke with paresis, taking carbidopa/levodopa, donepezil or antidepressants)

Design outcomes

Primary

Measure	Time frame	Description
Post operative complications	30 days after surgery	Comprehensive Complication Index (CCI)

Secondary

Measure	Time frame	Description
6 Minutes Walk Test Distance	4 weeks after discharge	—
Hospital Length of Stay	3-6 days	—
Anxiety and Depression	30 days after discharge	Using the Hospital Anxiety Depression Scale (HADS)
Health Related Quality of Life	30 days after discharge	Using the Short Form Health Survey (SF-36)
Readmission rates	30 days after discharge	—

Other

Measure	Time frame	Description
Cost Effectiveness of treatment	30 days after hospital discharge	Factoring the cost of the program versus possible savings related to other primary and secondary outcomes

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 10, 2026