STAPHYLOCOCCAL INFECTIONS
Conditions
Keywords
staphylococcus aureus, digestive carriage, mucosal colonization
Brief summary
Epidemiological study aiming to describe the carriage (nasal, throat, groin, rectal and colonic) of S. aureus in patients without chronic digestive disease who are going to have a colonoscopy for cancer screening. The carriage will be analyzed globally and the similarity of strains isolated from each site will be analyzed using molecular tools. The aim of this study is to better estimate the digestive reservoir of S. aureus to better prevent endogenous infections due to this bacterium.
Interventions
nasal, throat, rectal and groin sampling with swabs. Colonic sampling by colonic biopsy
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patient affiliated to French social security * Written consent of the patient * Patient needing a colonoscopy in the University Hospital of Saint-Etienne, France
Exclusion criteria
* Patient who decline to participate to the study * Patient in the incapacity to give consent * Patient receiving treatment with anticoagulant or antiaggregant platelets * Patients with a known haemostatic disorder * Pregnant woman * Patients with a chronic disease of the gastrointestinal tract * Patients receiving long-term corticosteroid * Patient receiving anti staphylococcal antibiotics
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of patient with Staphylococcus aureus colonic carriage | Day 1 | Staphylococcus aureus carriage in the colon is measured by biopsy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of patient with similar Staphylococcus aureus strains in the nose and in the rectum | Day 1 | Staphylococcus aureus carriage in the rectum and in the nose is measured by swab culture |
| Number of patient with Staphylococcus aureus carriage in the nose | Day 1 | Staphylococcus aureus carriage in the nose is measured by swab culture. |
| Number of patient with Staphylococcus aureus carriage in the throat | Day 1 | Staphylococcus aureus carriage in the throat is measured by swab culture. |
| Number of patient with Staphylococcus aureus carriage in the groin | Day 1 | Staphylococcus aureus carriage in the groin is measured by swab culture. |
Countries
France
Outcome results
None listed