Fasciculations
Conditions
Brief summary
To investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations.
Detailed description
Ninety patients scheduled for laparoscopic cholecystectomies were equally randomized into three groups to receive pretreatment of 0.005, 0.01, and 0.02 mg/kg cisatracurium, respectively. General anesthesia was induced 3.5 min later, train of four stimulation was monitored 4.5 min later, succinylcholine 1.5 mg/kg was injected 5 min later, and endotracheal intubation was implemented 6.5 min later. The side effects of cisatracurium, intensity of fasciculations, intubating conditions, time and extent to maximal depression of twitch and time for its recovery to 20% of control value, severity of myalgia at 24 h postoperatively, serum potassium before cisatracurium pretreatments, at intubating time, and 5 min after intubation were recorded.
Interventions
DRUGCisatracurium
Different groups received different pretreatments of cisatracurium.
Sponsors
Zhuan Zhang
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* American Standards Association (ASA) physical status I or II patients scheduled for elective laparoscopic cholecystectomies with tracheal intubation requiring general anesthesia; * 20 - 65 years old; * Without acid-base imbalance and electrolyte disturbance; * With normal hepatic and renal function.
Exclusion criteria
* Patients with the contraindications associated with succinylcholine or cisatracurium; * Patients taking drugs known to alter the action of neuromuscular blockers; * Patients with a body mass index exceeding 30
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Presence of fasciculations | After the injection of succinylcholine for 1.5 minutes |
Secondary
| Measure | Time frame |
|---|---|
| The time to maximal depression of twitch | From the time of 4.5 minutes after the pretreatment of cisatracurium for two minutes |
| The extent to maximal depression of twitch | From the time of 4.5 minutes after the pretreatment of cisatracurium for two minutes |
| Side effects of the pretreatment of cisatracurium | From the time of 3 minutes after the pretreatment of cisatracurium for 0.5 minutes |
| The changes of serum potassium | After entering the operating theater till the anesthesia induction, at intubating, and 5 min after intubation |
| Myalgia at 24 hours postoperatively | At 24 hours postoperatively |
| The grades of endotracheal intubation | At intubating time |
Outcome results
None listed