Polycystic Ovary Syndrome
Conditions
Brief summary
Polycystic ovary syndrome (PCOS) has a heterogeneous clinical presentation comprising reproductive (hyperandrogenism, menstrual irregularity, anovulation, infertility, pregnancy complications), metabolic \[insulin resistance (IR), increased type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) risk factors\] and psychological features (worsened quality of life and increased anxiety and depression) Whether prolonged fasting during Ramadan breaks the insulin resistance state of polycystic ovarian syndrome and subsequently improve the ovulation and spontaneous pregnancy will happen without ovarian stimulation.
Detailed description
Question of the study: The question is raised whether prolonged fasting during Ramadan breaks the insulin resistance state of polycystic ovarian syndrome and improve the metabolic syndrome does prolonged fasting decrease glucose level, insulin level, insulin resistance markers such as adipokines and subsequently improve ovarian function and causes spontaneous ovulation.
Interventions
None listed
Sponsors
Ain Shams University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Females with PCO in child bearing age who presented at reproductive and endocrinology clinics at Ain Shams University Maternity Hospital, and welling to fast for 30 days from 5 am until 7 pm and do not plan to induce her ovulation in the next 4 months to get pregnant. * Does not have any other medical illnesses other than PCO. * Welling not to start any ovulation induction in the next 4 months after the first blood sample was taken and after fasting month.
Exclusion criteria
* Known androgen secreting tumor. * PCO on ovarian stimulation medications * PCO with any other medical illness. * Non-compliance with fasting 30 days from 5 am- 7 pm.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| spontaneous ovulation measured by midluteal progesterone | one month | Ovulation will be monitored by the Progesterone level on 22nd day of first cycle after 30 days of prolonged daily Fasting (Ramadan). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| clinical pregnancy | four months | We will record any pregnancy will happened in the next 4 months after Fasting without any ovulation induction. |
| fasting glucose/insuline ratio | one month | Insulin resistance (IR) measuring: fasting 8 hours. Plasma glucose (FPG) and fasting insulin (FIN) will be measured by chemiluminescent immunoassay. The ratio of glucose/insulin represents the degree of IR |
| Plasma adiponectin | one month | Plasma adiponectin will be measured before and after 30 days fasting |
| plasma resistin | one month | Plasma resistin will be measured before and after 30 days fasting |
| plasma gherlin | one month | Plasma gherlin will be measured before and after 30 days fasting |
Countries
Egypt
Outcome results
None listed