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The Effects of Carbohydrate Source on Food Intake, Blood Glucose and Gut Hormone Response in Healthy Children

The Effects of Potatoes and Other Carbohydrate Side Dishes Consumed With Meat on Food Intake, Glycaemia and Satiety Response in Children

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02499107
Enrollment
32
Registered
2015-07-15
Start date
2013-04-30
Completion date
2015-12-31
Last updated
2017-05-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes, Obesity

Keywords

food intake, satiety, blood glucose, potato, insulin

Brief summary

This study will compare the effects of commonly consumed carbohydrate sources such as potatoes, pasta and rice along with a fixed portion of meat on blood glucose, satiety and insulin levels among healthy body weight children. Healthy boys and girls, aged between 11 - 13 years old, will be involved in this study.

Detailed description

The prevalence of childhood obesity and overweight has become a major health concern worldwide. Prevention of overweight and obesity in children is a high priority because they are at high risk of becoming obese adults and obesity is predictive of the development of coronary heart disease, hypertension and diabetes. Thus, there is a need for food-based solutions to increase satiety and subsequently reduce energy intake. Over the past 40 years, the consumption of potatoes has decreased by 41% which may be a consequence of movements aimed at decreasing serving sizes, or the outright banning, of potato foods from cafeterias and quick service restaurants such as French fries due to the observational studies showing they are linked with increased risk of obesity. Alternate energy dense starches such as rice and pasta have increased in consumption as a result for meal accompaniments with no discernible decrease in the upward trajectory of the number of overweight and obese individuals. These recent trends may be a consequence of individuals ignoring vital information such as the substantial nutrient content as well as the overall balance and low energy density to nutrient density ratio of the potato in addition to other beneficial components. Compounding this, research has also indicated that the GI of potatoes is high relative to other starches, in spite of recent evidence suggesting a high variability in these measurements or little consideration taken for the preparation method of the potato (potato chips vs. baked potato, for example). Additionally, potatoes are commonly consumed with other foods which in turn often significantly lower the GI of the meal when compared to consumption of the potato alone. For example, Estima potatoes ingested with 62 g of cheddar cheese reduced the GI from 93 to 39 and mashed potatoes served with oil, chicken breast and salad (representing a meal) reduced the GI of the potato from 108 to 54. The GI is based on the consumption of a fixed amount of available carbohydrate, which may not be representative of the glycaemic effect of the amount of carbohydrate usually consumed in a serving of a food within a meal, such as the case with potatoes. We have extensive experience in conducting experimental studies especially with children. Previously in our laboratory, we investigated and published numerous studies focused on assessing food intake (FI) regulation and appetite in children aged 9 to 13 years. Thus, the purpose of the current study is to determine effects of commonly consumed carbohydrate sources such as potatoes, pasta and rice along with a fixed portion of meat on blood glucose, satiety and insulin levels among healthy body weight children (aged 11 to 13 years) over a 2 hour period.

Interventions

DIETARY_SUPPLEMENTRice treatment

All arms are given to all participants, in a randomized (cross over) order

DIETARY_SUPPLEMENTPasta treatment
DIETARY_SUPPLEMENTBoiled and mashed potato treatment
DIETARY_SUPPLEMENTBaked french fries treatment
DIETARY_SUPPLEMENTFried french fries treatment

Sponsors

University of Toronto
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
11 Years to 13 Years
Healthy volunteers
Yes

Inclusion criteria

* boys and girls * age 11 to 13 years old * healthy * BMI-for-age percentile 15% to 85%

Exclusion criteria

* taking any medications, * Parental report of children with major disease, * behavioral or emotional difficulties, * children who have a food allergy, * children follow a therapeutic diet, or do not habitually eat breakfast

Design outcomes

Primary

MeasureTime frameDescription
Food IntakeFood intake will be measured at 30 min after ad libitum carbohydrate intakeFood intake (kCal) will be assessed 30 min after consumption of the ad libitum treatments of either rice, pasta, boiled and mashed potatoes, baked french fries or fried french fries.

Secondary

MeasureTime frameDescription
Plasma Insulin hormoneInsulin will be measured at 0, 30, 60 and 120 min - during the 2 hours study period.Plasma Insulin hormone will be measured using intra-venous blood sample
Plasma Glucogan like peptide (GLP-1) hormoneGLP-1 will be measured at 0, 30, 60 and 120 min - during the 2 hours study period.Plasma GLP-1 hormone will be measured using intra-venous blood sample
blood glucoseblood glucose will be measured at 0, 30, 45, 60, 75, 90 and 120 min - during the 2 hours study period.Blood glucose (mmol/L) will be measured using finger prick capillary blood samples
Peptide YY (PYY) hormonePYY hormone will be measured at 0, 30, 60 and 120 min - during the 2 hours study period.Plasma PYY hormone will be measured using intra-venous blood sample
subjective appetiteSubjective appetite will be measured at 0, 30, 45, 60, 75, 90 and 120 min - during the 2 hours study period.Subjective appetite will be measured by using visual analouge scales
Plasma ghrelin hormoneActive ghrelin hormone will be measured at 0, 30, 60 and 120 min - during the 2 hours study period.Plasma ghrelin hormone will be measured using intra-venous blood sample

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026