Generalized Chronic Periodontitis, Pulmonary Disease, Chronic Obstructive
Conditions
Keywords
Pulmonary disease,chronic obstructive,, generalized chronic periodontitis, SERPINA1 gene polymorphism
Brief summary
Chronic obstructive pulmonary disease and periodontitis are chronic inflammatory diseases. The study aims to determine if the genetic polymorphism of SERPINA1 gene in patients with COPD serve as a risk factor for developing periodontitis.
Detailed description
periodontitis is a polymicrobial inflammatory disease caused by various modifiable and non-modifiable risk factors. the non-modifiable risk factors include genetic polymorphisms like the gene coding for alpha-1-antitrypsinase COPD is a chronic inflammatory disease characterized by deterioration of lung function due to loss of elasticity of the lungs. SERPINA1 gene product has a protective role on the connective tissue components of both lungs and gums. Hence, this study tries to determine if the gene polymorphism in COPD serves as a risk factor for developing periodontitis.
Interventions
GENETICSERPINA1 gene
2ml blood sample collected from patients to extract DNA for assessment of SERPINA1 gene polymorphism
Sponsors
Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Male and female patients aged between 30-70yrs diagnosed with COPD and chronic periodontitis who are willing to participate in the study.
Exclusion criteria
* Pateints with other systemic disorders * patients not willing to participate in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SERPINA1 gene polymorphism | 9 months | of blood samples and running samples by PCR |
Countries
India
Outcome results
None listed