Coronary Artery Calcification
Conditions
Keywords
maintenance hemodialysis patients, coronary artery calcification, low calcium dialysate, effects, safety
Brief summary
This study aim to observe the preventive effect and the long term safety of low calcium dialysis on coronary artery calcification in Maintenance hemodialysis (MHD) patients.
Detailed description
MHD patients recruited in this study were randomly divided into two groups: routine dialysis group (with dialysate calcium concentration 1.5mmol/L) and low calcium dialysis group (with dialysate calcium concentration 1.25mmol/L). All patients were dialyzed thrice weekly for 4 hours with a bicarbonate-based solution. They were followed up in every dialysis interview during the 1-year study, the occurrence of all adverse reactions associated with dialysis were recorded during the study. All patients received heart spiral CT examination before and at the end of the study. Coronary artery calcification was assessed by a certain professional who was not affiliated to the dialysis center.
Interventions
OTHERlow calcium dialysis
patients in this group will receive low calcium dialysis for 1 year.
Sponsors
First Affiliated Hospital of Chongqing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Maintenance hemodialysis (MHD) patients who dialyze thrice weekly in our hospital with serum iPTH \<500pg/ml, adjusted serum calcium≧8.4mg/dl in two serial tests. * Patients who have no chronic infection or malignant tumour and with relatively stable heart and lung function. * Patients who signed informed consent documents at the time of enrollment in the study.
Exclusion criteria
* Patients whose heart or lung function are poor, or with unstable hemodynamics. * Patients who are diagnosed active pulmonary tuberculosis, AIDS, malignant tumour, or decompensated liver cirrhosis. * Patients who are unable or unwilling to cooperate with the researchers in the treatment and follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in coronary artery calcification after 1 year's treatment | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| The intolerance of low calcium dialysis because of adverse reactions associated with dialysis were recorded during the study | 1 year |
Countries
China
Contacts
Primary ContactYunfeng Xia, Dr.
Outcome results
None listed