Rhabdomyolysis
Conditions
Brief summary
In order to determine norm values for skeleton muscle disassembly due to physical exertion in healthy and trained population, and developing a prediction test for approval for rhabdomyolysis injuries to return to duty, 50 healthy subjects will undergo a series of different physical tests.
Detailed description
50 healthy civilians volunteers will be recruited for this study. Each subject will undergo the physical tests: anthropometric measurements, wingate test, VO2max test, step test and running on the anaerobic threshold, on separate days. Blood sample, lactic acid level (measured in blood drop - finger sting) and urine sample will be taken before and after every test.
Interventions
OTHERphysical tests
each subject will undergo the following physical tests: day 1 - anthropometric measurements, wingate test and after 1 hour rest VO2max test. lactic acid levels will be measured before and after both tests. day 2 - step test day 3 - running on the anaerobic threshold. blood sample, lactic acid level (measured in blood drop - finger sting) and urine sample will be taken before and after every test in days 2 and 3.
Sponsors
Sheba Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy civilians ages 18-30. * above average aerobic and anaerobic fitness. * Without heart, cardiovascular, metabolic or respiratory illnesses. * Without known medical illness or medication use that might endanger the participants.
Exclusion criteria
* existence of any of undesired conditions detailed in the inclusion criteria. * the physician decision.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| creatine phosphokinase (CPK) | 5 experiment days for each subject | CPK is a marker for muscle damage assessed in blood test. blood sample will be taken before and after step test and running on the anaerobic threshold test. |
| oxygen consumption (VO2) | 5 experiment days for each subject | VO2 will be monitored continuously using a metabolic system (ERGOTEST 680, ZAN, GERMANY ) during VO2max test, step test and running on the anaerobic threshold test. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| lactic acid | 5 experiment days for each subject | lactic acid level is assessed from blood drop (finger sting), will be taken before and after every test. lactic acid is a marker for anaerobic effort evaluating. |
| Myoglobin | 5 experiment days for each subject | marker from urine sample, taken before and after step test and running on the anaerobic threshold test. |
| Heart rate | 5 experiment days for each subject | The heart rate will be monitored using a wearable heart rate monitor (Polar® sensor and heart rate monitor watch). |
Countries
Israel
Contacts
Primary ContactOfir Frenkel, M.D
Outcome results
None listed