Functional Neural Connectivity at Rest as a Diagnostic Tool for Intolerance to Heat

Functional Neural Connectivity at Rest, as a Diagnostic Tool for Intolerance to Heat and Return to Duty After Exertional Heat Stroke

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02498158

Acronym

fMRI

Enrollment

Registered

2015-07-15

Start date

2015-09-30

Completion date

2016-12-31

Last updated

2015-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Functional Neural Connectivity

Brief summary

Functional neural connectivity at rest of 3 groups (heat tolerant, heat intolerant and healthy subjects) will be assessed using the anatomical and functional MRI scans and compared.

Detailed description

20 healthy subjects that had already underwent Heat Tolerance Test (HTT) at the Heller Institute of Medical Research (Sheba Medical Center) will be recruited and divided into 2 groups: heat tolerant and heat intolerant (according to the HTT results). They will be asked to arrive to one experimental day at the imaging department in Sheba Medical Center and undergo anatomical and functional MRI scans. Third group will consist of 10 existing brain scans (separated from personal details) of healthy males, at the same age range and who had never gone through heat injury. Data will be analysed by fMRI expert in order to compare the functional neural connectivity at rest between the three groups.

Interventions

DEVICEMRI scans

20 subject (10 tolerant and 10 intolerant to heat) will undergo MRI scans (GE healthcare manufacturer) as follows: 1. anatomical scan according to standard protocol 2. functional scan according to the standard protocol of rest-state fMRI. scans of 10 healthy subjects will be taken from existing scans at the imaging department.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

18 Years to 25 Years

Healthy volunteers

Yes

Inclusion criteria

* generally healthy subjects * underwent heat injury in the past two months * underwent Heat Tolerance Test at the Heller Institute of Medical research

Exclusion criteria

* drug or alcohol use * history of neurological disorders, mental retardation or head injury * history or diagnosis of psychiatric disorders * claustrophobia

Design outcomes

Primary

Measure	Time frame	Description
functional neural connectivity	one day	MRI scans will be interpreted by fMRI expert and then compared between heat tolerant and intolerant subjects.

Countries

Israel

Contacts

Primary ContactOfir Frenkel, M.D

Ofir.Frenkel@sheba.health.gov.il+972529243399

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026