Sleep Deprivation
Conditions
Keywords
sleep deprivation
Brief summary
This study aimed to investigate the effect of 48-h sleep deprivation on heart rate variability (HRV) in young healthy people and the protective effect of statin on arrhythmia and HRV.
Detailed description
In the setting of earthquakes, floods, or fire disasters, rescue workers usually carry out their work without sleep. Sleep deprivation (SD), which is a strong stressor, can exert a large effect on the cardiovascular system of rescue workers. It has been reported that SD is associated with arrhythmia, dyslipidemia and type 2 diabetes. Heart rate variability (HRV) is acknowledged as a reliable marker of cardiac autonomic control, and the frequency of premature ventricular complexes can be an indicator of arrhythmogeneity. The investigators found that HRV was significantly decreased after 24-h sleep deprivation. Metoprolol could improve HRV and reduce the frequency of premature atrial and ventricular complexes. But sleepiness and hypotension occurred frequently in subjects treated with metoprolol. Statins have significant cardiovascular protective effects in patients with cardiovascular disease. Statin not only could regulate serum lipid level, but also have antioxidant and anti-inflammatory properties. This study aimed to investigate (1) the changes in heart rate variability and occurrence of cardiac arrhythmia by continuous ambulatory electrocardiogram (ECG) in young, healthy subjects undergoing 48h SD and (2) the effects of statin on HRV and arrhythmia after this agent was administered prophylactically before SD.
Interventions
DRUGAtorvastatin
atorvastatin were taken daily for 5 days
DRUGplacebo
placebo were taken daily for 5 days
Sponsors
Shi Yang
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy subjects without cardiovascular disease
Exclusion criteria
* hypertension * diabetes mellitus * hyperthyroidism * taking medication known to affect cardiovascular, metabolic, gastrointestinal, or immune function * depression * anxiety disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| a change in low-frequency (LF)/ high frequency (HF) | 48-h sleep deprivation | The primary efficacy endpoint was the effect of statin on LF/HF measured by continuous ambulatory electrocardiogram monitoring after 48-h sleep deprivation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| a change in the frequency of premature atrial and ventricular complexes | 48-h sleep deprivation | The frequency of premature atrial and ventricular complexes during 48-h sleep deprivation were measured by continuous ambulatory electrocardiogram monitoring |
| a change in serum total cholesterol level | 48-h sleep deprivation | serum total cholesterol level was measured after 48-h sleep deprivation |
| a change in serum high sensitivity C-reactive protein level | 48-h sleep deprivation | serum high sensitivity C-reactive protein level was measured after 48-h sleep deprivation |
| a change in serum superoxide dismutase level | 48-h sleep deprivation | serum superoxide dismutase level was measured after 48-h sleep deprivation |
Other
| Measure | Time frame | Description |
|---|---|---|
| a composite outcome (the incidences of treatment-emergent adverse events) | 48-h sleep deprivation | Treatment-emergent adverse events (TEAEs): abnormal liver function, renal insufficiency and constipation |
Countries
China
Contacts
Primary Contactyang shi, M.D.
Outcome results
None listed