Acute Effects of Fats on Satiety and Energy Needs

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02496936

Enrollment

Registered

2015-07-14

Start date

2015-12-31

Completion date

2019-10-30

Last updated

2022-08-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

Energy Expenditure, Appetite, Satiety

Brief summary

The purpose of this study is to assess the acute effect of dietary fat on satiety and energy metabolism.

Detailed description

The influences of specific dietary fat sources on satiety, appetite and energy utilization remains unclear; evidence is lacking on whether responses vary according to acute intake. The researchers will use a controlled setting to determine whether the source of dietary fat is related to perceived satiety, satiety hormone responses, and energy expenditure by conducting experiments to evaluate short term (acute) effects.

Interventions

OTHERSFA

High saturated fatty acid/SFA oil source

OTHERMUFA

High monounsaturated fatty acid/MUFA oil source

OTHERPUFA-LA

High polyunsaturated fatty acid (linoleic)/PUFA-LA oil source

OTHERALA

High polyunsaturated fatty acid (alpha-linolenic)/ALA oil source

OTHERLCn3

High polyunsaturated fatty acid (omega-3)/LCn3 oil source

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

OTHER

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* body mass index between 18.0-34.9 kg/m2 * free of major diagnosed, untreated medical conditions * controlled hypertension * non-smoking or use of other tobacco products, including e-cigarettes * not taking steroid-based medications * not planning to or currently attempting to gain or lose weight * willing to comply with study demands * use of oral contraceptives * low intake of long chain omega 3 fatty acids

Exclusion criteria

* diagnosed eating disorders * diabetes (blood sugar ≥ 126 mg/dl) * hypertension (systolic ≥ 160 mmHg or diastolic \> 100 mmHg) * diagnosed cardiovascular, pulmonary, skeletal and metabolic disease * currently pregnant or planning to become pregnant, or lactating * taking medications known to affect appetite, blood lipids, body composition, body weight, or food intake (appetite control drugs, steroids, antidepressants)

Design outcomes

Primary

Measure	Time frame
Acute effect of fat intake on energy expenditure as determined by metabolic rate	Incremental Area Under the Curve (iAUC) of metabolic rate from 0 to 4 hours

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026