Clinical Pregnancy Rate, IVF, Ovulation Induction
Conditions
Brief summary
Pituitary down regulation is widely used during in vitro fertilization (IVF) procedures. It can suppress the spontaneous luteinizing hormone (LH) surge, and can also make follicles growth evenly. At present, standard gonadotropin releasing hormone analogue (GnRH-a) long protocol is used in arou Long term GnRH-a, which is usually used in patients with endometriosis,has been shown to increase IVF outcome by altering endometrial receptivity. Moreover, it is also very convenient because patients do not have to inject GnRH-a daily. In order to make patients feel more comfortable during IVF treatment, the investigators have used a new ovarian stimulation protocol since the beginning of 2015. The investigators give patients long term GnRH-a (3.75mg) once at menstrual cycle D2, and begin the use of Gn to stimulate follicle growth around 30 days later based on the hormone levels and follicle size. In the pilot observational study of several patients, no LH surge occurred during ovarian stimulation. The aim of this randomized controlled study is to compare the efficiency of this new protocol and standard GnRH-a long protocol in the investigator's center.
Detailed description
The primary outcome is clinical prengancy rate. Secondary outcome is cumulative live birth rate. Other parameters include number of oocytes retrieved, 2 pronucleus (2PN) fertilization rate, high quality embryo formation rate, implantation rate, spontaneous abortion rate, and ectopic pregnancy rate.
Interventions
DRUGGnRH-a
In experimental group, patients use long term GnRH-a; Patients' serum or follicle fluid will be collected if needed.
DRUGGnRH-anta
In control group, patients use GnRH-antagonist. Patients' serum or follicle fluid will be collected if needed.
Sponsors
The First Affiliated Hospital of Zhengzhou University
Study design
Allocation
NA
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
22 Years to 38 Years
Healthy volunteers
No
Inclusion criteria
* First IVF cycle; * With normal ovarian reserve(FSH \< 10 mIU/mL; antral follicle count\>5); * With normal uterine. * PCOS women according to Rotterdam criteria
Exclusion criteria
* Pre-implantation genetic diagnosis cycles; * Oocyte donation or sperm donation cycles.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| clinical pregnancy rate | 5 weeks after embryo transfer | 5 weeks after embryo transfer, gestational sac with fetal heart present inside uterus |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cumulative live birth rate | 2 years after oocyte retrivial | — |
| Number of oocytes retrieved | 1 day at oocyte retrieved day | — |
| 2 pronucleus (2PN) fertilization rate | 48 hours after oocyte retrieved day | Number of 2PN/Matured oocytes |
Countries
China
Outcome results
None listed