Pain, Postoperative, Pregnancy
Conditions
Keywords
NAV1.7 Voltage-Gated Sodium Channel, pain, postoperative, cesarean section
Brief summary
The purpose of this study to determine the association between postoperative pain after cesarean section and several single nucleotide polymorphisms in SCN9A sodium channels gene.
Detailed description
SCN9A gene encodes an alpha subunit of the voltage-gated sodium channel (Nav1.7) and polymorphisms of this gene are associated with severe pain disorders. The impact of the polymorphisms in SCN9A on postoperative pain and opioid consumption after cesarean section is unclear.
Interventions
PROCEDUREcesarean section
Women in 36 to 40 weeks of pregnancy undergoing cesarean section by Pfannenstiel technique
DRUGOpioid Tramadol
Tramadol will be administered via patient controlled analgesia (PCA) pump in the postoperative period
Sponsors
Tokat Gaziosmanpasa University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* The women aged 18 to 45, * in 36 to 40 weeks of pregnancy * undergoing cesarean section
Exclusion criteria
* History of chronic pain or pain disorders * Psychiatric diseases * Diabetes mellitus * Severe cardiovascular, kidney or liver diseases * Alcohol or drug abuse * Heavy smoker * Unable to use the Patient controlled analgesia (PCA) pump
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain | up to postoperative 24 hours | The pain will be evaluated with the visual analog scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Opioid consumption | Up to postoperative 24 hours | The total amount of the tramadol administered to the patient will be recorded |
Countries
Turkey (Türkiye)
Outcome results
None listed