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Comparison of Two Physical Activity Interventions in Individuals With Multiple Sclerosis

Comparison of Two Physical Activity Interventions in Individuals With Multiple Sclerosis: A Randomized Clinical Trial

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02496416
Enrollment
30
Registered
2015-07-14
Start date
2016-08-31
Completion date
2022-12-31
Last updated
2022-12-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis

Brief summary

This study will examine the effectiveness of aquatic therapy on a range of MS-related symptoms such as cognition, mood, fatigue and quality of life (QOL).

Detailed description

Aim 1. Examine the impact of aquatic exercise on cognitive abilities. The proposed study will test the hypotheses that, compared to the wait-list control group, the treatment group will demonstrate significantly greater improvements in cognitive outcomes, specifically: processing speed, executive functioning, working memory and long-term memory. Aim 2. The current study will examine the impact of an aquatic exercise on fatigue, mood, wellness, QOL and physical functioning. Specifically the investigators predict that aquatic exercise will lead to improvements in: 1.Fatigue 2. Health related QOL 3. Depression/anxiety 4. Self-efficacy 5. Physical Functioning (i.e. gait and walking). Aim 3: Examine the long-term effects of aquatic exercise on all outcome measures.

Interventions

The aquatic exercise program will consist of 45 minute classes held 3 days/week for 8 weeks (18 hours total). The program is based on guidelines provided by the National Multiple Sclerosis Society (NMSS) and will be led by an aquatic fitness instructor certified to teach individuals with MS at the YMCA in Scotch Plains-Fanwood. The exercises will focus on improving flexibility, balance and strength. Equipment such as water mitts, paddles, noodles and bands will be used to increase the level of difficulty as needed.

The stretching program will consist of 45 minute classes held 3 days/week for 8 weeks (18 hours total). The program is based on guidelines provided by the National Multiple Sclerosis Society (NMSS) and will be conducted online via a secure video-conferencing website.

Sponsors

National Multiple Sclerosis Society
CollaboratorOTHER
Kessler Foundation
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* diagnosis of MS. * between the ages of 18-65. * read and speak English fluently.

Exclusion criteria

* history of significant substance abuse. * history of neurological disease other than MS (for example, stroke, epilepsy, or brain injury). * history of significant psychiatric illness (for example, bipolar disorder or schizophrenia). * has engaged in more than 30 minutes of moderate to strenuous exercise per week during the past six months.

Design outcomes

Primary

MeasureTime frameDescription
Cognition measured by results of standardized neuropsychological tests8 weeksstandardized measures of processing speed, executive functioning, working memory and long-term memory

Secondary

MeasureTime frameDescription
Quality of Life measured by self report questionnaires8 weeksGeneral QOL measured with Satisfaction with Life Scale (SWLS) and HRQOL measured with Health Status Questionnaire (HSQ).
Fatigue measured by self-report questionnaires8 weeksModified Fatigue Impact Scale (MFIS) and Fatigue Severity Scale (FSS\_

Countries

United States

Contacts

Primary ContactAngela Smith, MA
asmith@kesslerfoundation.org973-324-8448

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026