Coronary Artery Disease
Conditions
Keywords
Coronary Artery Bypass Graft Surgery, Acute kidney injury, Renal failure, Biomarker
Brief summary
Cardiac surgery associated acute kidney injury (CSA-AKI) has been recognized as the second most common cause of hospital acquired AKI. The development of CSA-AKI is independently associated with an increased risk of in-hospital death. There are currently no biomarkers that could identify patients at higher risk for AKI and current risk predictor scores that are based on clinical and demographic information are inadequate. Therefore, a diagnostic test for predicting AKI risk in this clinical context would assist clinicians to optimize surgical strategy and postoperative care to prevent CSA-AKI occurrence and improve patient outcomes. The primary purpose of this study is to measure the association between baseline expression of senescence markers in blood using SenesceTest and the occurrence of CSA-AKI post surgery.
Interventions
None listed
Sponsors
Duke University
Sapere Bio
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients must fulfill all criteria to be eligible for this study: * Adult patients (\>18 yo) undergoing non-emergency cardiac surgery using cardiopulmonary bypass (CABG, combined CABG/valve, or valve surgery).
Exclusion criteria
Patients who fulfill any of the following criteria will be excluded: * Emergency surgery. * Off-pump coronary bypass grafting. * Aortic aneurysm repair. * Congenital heart disease repair. * Heart transplant or LVAD patient. * Severe heart failure (LVEF\<25%). * Hemodynamic instability or requiring preoperative vasopressors or IABP. * Pre-existing end-stage kidney disease (eGFR\< 15 mL/min/1.73 m2) or renal transplantation. * Presence of major active infection (chronic or acute, e.g. sepsis, HIV, pneumonia). * Chronic liver disease /cirrhosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Development of stage 1 or higher postoperative AKI as defined by the AKIN classification (stage 1- ≥ 0.5 mg/dL absolute or ≥ 50% relative rise in peak SCr over the baseline) | 48-72 hours |
Secondary
| Measure | Time frame |
|---|---|
| Number of Participants who suffered cognitive decline | 30 days |
| Number of Participants requiring prolonged mechanical ventilation (for longer than 24h) | 30 days |
| Number of Participants with : cardiac arrest, perioperative myocardial infarction and perioperative ventricular dysfunction. | 30 days |
| Number of Participants with cardiac arrest | 30 days |
| Number of Participants with perioperative myocardial infarction | 30 days |
| Number of Participants with perioperative ventricular dysfunction. | 30 days |
| Number of Participants who suffered postoperative stroke | 30 days |
| Number of Participants with postoperative thoracotomy infection | 30 days |
| Number of Participants with postoperative sepsis. | 30 days |
| Number of Participants in need for renal replacement therapy | 30 days |
| Number of Participants who progressed to end stage renal disease. | 30 days |
| Death | 1 year |
| Number of Participants with postoperative deep sternal wound infection | 30 days |
Countries
United States
Outcome results
None listed