Postpartum Bleeding
Conditions
Keywords
Postpartum hemorrhage, Third stage of labour, Oxytocin, Uterotonics, Active management of third stage of labour
Brief summary
The investigators are planning to determine the effect of the timing of oxytocin administration on the amount of blood loss, necessity for additional medical or surgical interventions.
Detailed description
The investigators are studying the effects of the timing of intramuscular oxytocin administration in the third stage of labour. The investigators are measuring the postpartum blood loss: quantitatively in the postpartum 1st hour and indirectly by the decrease in the hemoglobin-haematocrit levels in the postpartum 24th hour. The investigators are monitoring the length of the third stage of labour, and the need for extra uterotonics and/or surgical interventions.
Interventions
DRUGOxytocin
Oxytocin 10IU Administered intramuscularly.
Sponsors
Kanuni Sultan Suleyman Training and Research Hospital
Bagcilar Training and Research Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Cephalic presentation * Singleton pregnancy * Gestational age \>35 weeks, * In active labour. * Expected fetal birth weight 2500-4500 grams.
Exclusion criteria
* Acute Fetal Distress * Conversion to abdominal delivery * Persistent high blood pressure (\>140/90mmHg) * Placenta Previa * Ablatio placenta * Previous C-Section * Uterine scar * Postpartum hemorrhage in previous pregnancies. * Hydramnios * Maternal infection * Forceps/Vacuum Assisted deliveries * Abnormal placentation ( Placenta accreta, increta or percreta) * Coagulation Defects * Hemoglobin \< 8g/dl
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postpartum blood loss >500cc | Participants will be followed for the duration of hospital stay, an expected average of 24 hour | Number of participants whose blood loss is higher than 500cc. |
| Postpartum blood loss | Participants will be followed for the duration of hospital stay, an expected average of 24 hour | Quantitative collection of blood loss. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Need for additional uterotonics | Participants will be followed for the duration of hospital stay, an expected average of 24 hour | Additional uterotonics (Oxytocin 10IU; Cytotec tb Rectal and/or vaginal) were administered if postpartum blood loss \>500ml OR uterine atony was observed OR sudden excessive hemorrhage was encountered. |
| Duration of the third stage of labour. | Participants will be followed for the duration of labor unit stay, an expected average of one hour | — |
| Manual removal of the placenta. | At first hour after delivery of the fetus | — |
| Postpartum transfusion | Participants will be followed for the duration of hospital stay, an expected average of 24 hour. | — |
| Drop in the hemoglobin and hematocrit levels | At the 24th hour,postpartum | — |
Countries
Turkey (Türkiye)
Contacts
Primary ContactDogukan Yildirim, MD
Backup ContactEser S Ozyurek, MD
Outcome results
None listed