Coronary Disease
Conditions
Keywords
Coronary Angiography, Exercise
Brief summary
The primary purpose of this study is to investigate if systematic, high intensity, interval-based aerobic exercise training results in regression of lipid content of atherosclerotic coronary artery plaques, and in reduction of plaque burden in patients with stable coronary heart disease. Composition and morphologic characteristics of plaques will be studied by intra-coronary near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) in patients undergoing percutaneous coronary intervention.
Interventions
BEHAVIORALhigh intensity interval-based aerobic exercise
Interval exercises done 3 times weekly during 6 months according to standard procedures at the Department of Circulation and Medical Imaging.
OTHERUsual care
Sponsors
St. Olavs Hospital
Norwegian University of Science and Technology
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* stable coronary artery disease * will undergo cardiac catheterization * will be treated with percutaneous coronary intervention (PCI) * signed written informed consent * able to execute the intervention
Exclusion criteria
* earlier bypass surgery * known inflammatory disease other than atherosclerosis * planned surgery within 4 months * included in another randomized controlled study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| lipid content of atherosclerotic coronary artery plaques | 6 months | Lipid core burden index (LCBI) measured by intracoronary near-infrared spectroscopy |
Countries
Norway
Outcome results
None listed