Antioxidant and Anti-inflammatory Effects of Yogurt Enriched With Polyphenols

Investigation of the Antioxidant and Anti-inflammatory Effects of Yogurt Enriched With Polyphenols

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02494739

Enrollment

Registered

2015-07-10

Start date

2015-05-31

Completion date

2015-06-30

Last updated

2016-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation, Oxidative Stress

Keywords

antioxidant, oxidative stress, inflammation, polyphenols, yogurt

Brief summary

The purpose of this study is to investigate the possible antioxidant and anti-inflammatory effects of yogurt enriched with polyphenols after 2-week consumption by healthy individuals.

Detailed description

Eighteen healthy adult volunteers of both sexes consumed yogurt (400g per day) enriched with polyphenols (10mg/100g yogurt) or yogurt (400g per day) not enriched with polyphenols for two weeks in a double-blind, crossover, randomized manner.There was a washout period of at least 10 days. Physiological data and blood samples were collected before and after consumption of each yogurt.

Interventions

OTHERYogurt enriched with polyphenols

Yogurt enriched with polyphenols extracted from grape seeds

OTHERYogurt not enriched with polyphenols

Yogurt not enriched with polyphenols

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy individuals * Non-smokers

Exclusion criteria

* Current use of dietary supplements or drugs * Metabolic disease * Lactose intolerance * Pregnant, pregnancy intention or breast feeding

Design outcomes

Primary

Measure	Time frame	Description
Antioxidant effects	Two weeks	Indices of blood antioxidant status
Anti-inflammatory effects	Two weeks	Indices of inflammation in blood

Secondary

Measure	Time frame	Description
Hydration	Two weeks	Urine specific gravity
Resting heart rate	Two weeks	Resting heart rate
Blood glucose levels	Two weeks	—
Body composition	Two weeks	Body fat percentage
Total cholesterol levels	Two weeks	—
High Density Lipoprotein cholesterol levels	Two weeks	—
Triglyceride levels	Two weeks	—
Blood pressure	Two weeks	Blood pressure at rest

Countries

Greece

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026