Acute Coronary Syndrome, Sleep Apnea, Obstructive
Conditions
Keywords
Obstructive sleep apnea, Resistive inspiratory muscle training, Coronary artery disease, Cardiac rehabilitation
Brief summary
Obstructive sleep apnea (OSA) syndrome affects up to 5% of the general population. The prevalence is multiplied by 13 in coronary artery disease (CAD) patients. Many studies have shown that OSA syndrome was the main risk factor for cardiovascular morbidity and mortality (RR = 9.1 \[95%, 2.6 to 31.2\]). If the value of treatment with Continuous Positive Airway Pressure (CPAP) in symptomatic CAD patients (daytime sleepiness and/or 2 clinical symptoms with Apnea Hypopnea Index (AHI) ≥ 20) appears to be established, treatment with CPAP in asymptomatic CAD patients (with AHI\> 30) may be too demanding. Alternative treatments are rare and results are highly variable. Therefore, it would be interesting to suggest other treatment modalities with moderate coronary and/or minimally symptomatic OSA syndrome.
Detailed description
This study aims to assess the relevance of inspiratory muscles strengthening on reducing AHI in CAD patients with moderate OSA (AHI between 15 and 30).
Interventions
DEVICEPOWERbreathe Fitness Plus, (POWERbreathe International Ltd, UK) [Inspiratory muscles strengthening]
CAD patients participated in a 6-week (20 sessions of training) resistive inspiratory muscle training (RIMT) program for 10 minutes twice daily at a training intensity of 70% of maximum inspiratory pressure (MIP).
OTHERControl
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients with moderate OSA (15 \<AHI \<30) * Period between acute coronary syndrome and inclusion \<60 days * Patients included in cardiac rehabilitation
Exclusion criteria
* Obstructive lung disease with Tiffeneau index less than 70%. * Restrictive lung disease with a reduction of total lung capacity (TLC) * Treatment for OSA or clinical context (comorbidity) justifying CPAP * Congestive heart failure, thoracic surgery by sternotomy * Spontaneous pneumothorax * Severe Asthma * Ruptured eardrum, or another disease of the middle ear, or acute sinusitis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| AHI Variation | At 6 weeks | It is the difference between the AHI at the inclusion et the AHI at 6 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Circumference of the neck in centimetre | At 6 weeks | in centimetre |
| Epworth questionnaire to evaluate the deficit of sleep | at 6 weeks | This questionnaire evaluates the deficit of sleep |
| Pittsburgh questionnaire to evaluate the quality of sleep | At 6 weeks | This questionnaire evaluates the quality of sleep |
| SF12 questionnaire to evaluate the quality of life | At 6 weeks | This questionnaire evaluates the quality of life |
Countries
France
Outcome results
None listed