Spinal Cord Injuries
Conditions
Keywords
autoantibodies
Brief summary
The purpose of this study is to determine the autoantibody profiles after spinal cord injury and their role in spontaneous functional recovery.
Detailed description
Most patients experience variable degrees of functional recovery after spinal cord injury (SCI), predominantly in the first months after lesion. In SCI animal models, autoantibodies are pathogenic and their titers rise up at the time when spontaneous recovery stops. The aim of this study is to determine the autoantibody profiles after SCI and to infer their relation with functional recovery. To achieve this, autoantibody profiles, biochemical, hematological and immune-related parameters (cytokines, chemokines and growth factors) will be determined from a serum blood sample and functional recovery will be evaluated accordingly to standardized scales.
Interventions
OTHERBlood collection
Blood collection from the subject's arm
Sponsors
Fundación Mutua Madrileña
Hospital Nacional de Parapléjicos de Toledo
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Traumatic or non-progressive vascular SCI * Less than 45 days after lesion * Any neurological level * Complete and incomplete lesions * If patient has been treated with glucocorticoids, it should have passed at least 7 days from the end of the treatment
Exclusion criteria
* Cauda equina syndrome * Autoimmune disorder * Tumor (even if benign) * Neurodegenerative disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in ASIA scores | 4 months |
Secondary
| Measure | Time frame |
|---|---|
| Change in neurological level of injury | 4 months |
| Change in ASIA impairment scale (AIS) | 4 months |
Other
| Measure | Time frame |
|---|---|
| Spinal cord independence measure (SCIM) | Until discharge from the hospital (6-12 months) |
Countries
Germany, Spain
Outcome results
None listed