Cholecystitis
Conditions
Brief summary
Many anesthesiologists use the Remifentanil for reducing a surgical pain and stabilizing a vital sign. However, this drug induce postoperative hyperalgesia. Nowadays, many studies report that low-dose Ketamine prevents the opioid-induces hyperalgesia. Nefopam,which is non-opioid analgesic, has similar mechanism with Ketamine. It will be helpful for postoperative pain control, and reduce the needs of opioid.
Interventions
DRUGNefopam
DRUGKetamine
DRUGSaline
Sponsors
Hallym University Kangnam Sacred Heart Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Inclusion criteria
* patient who scheduled laparoscopic cholecystectomy under general anesthesia * American Society of Anesthesiologist(ASA) class I or II * adult patient (age 20 - 65)
Exclusion criteria
* patient who has liver disease * patient who has kidney disease * patient who has diabetes mellitus(DM) or heart disease * patient who takes opioid or beta-blocker * patient who has airway disease * patient who has allergy with the drug
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| analgesic requirement | During 1 hour at PACU |
| duration of analgesic free | During 1 hour at PACU |
Secondary
| Measure | Time frame |
|---|---|
| Pain on the VAS scale | During 1 hour at PACU |
| analgesic requirement | During 8 hours after arriving at ward |
Countries
South Korea
Contacts
Primary ContactMi hyun Lee
Outcome results
None listed