Alzheimer's Disease
Conditions
Keywords
Alzheimer, Recognition Memory, Mild Cognitive Impairment, fMRI
Brief summary
Unrandomized, unblinded, monocentric comparative Functional Magnetic Resonance Imaging study.
Detailed description
Prospective functional Magnetic Resonance Imaging study involving a group of participants with Mild Cognitive Impairment due to AD and a control participants group matched for age, education level, verbal Intelligence Quotient as assessed through the French version of the National Adult Reading Test and income group following National Institute of Statistics and Economics Studies classification.
Interventions
OTHERNeuropsychological tests
Scales and tests to evaluate: * Global cognitive performance * Handedness * Memory functions performance * Gestural praxis functions performance * Lexical and semantic functions performance * Executive functions performance * Memory disorders * Way of life * Mood
DEVICEA cranial MRI
Sponsors
Rennes University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
Volunteers (pilot phase) * Aged 25 - 75 * French native speakers * Right-handed * Education level equal or superior to primary school leaving certificate * Free from any medical or psychiatric condition that may impact cognition * Having given written informed consent Volunteers (experimental phase) * Aged 60 - 75 * French native speakers * Right-handed * Education level equal or superior to primary school leaving certificate * Free from any medical or psychiatric condition that may impact cognition * Having given written informed consent AD-MCI participants * Aged 60 - 75 * French native speakers * Right-handed * Education level equal or superior to primary school leaving certificate * Fulfilling criteria for AD-MCI (Albert et al., 2011) * Have been seen in a memory medical center or in Memory Resources and Research Medical Center for cognitive symptoms * Free from any medical or psychiatric condition that may impact cognition * Able to understand and consent * Having given written informed consent
Exclusion criteria
MRI contraindications (all participants) * Claustrophobia * Wearing of any metal implant such as: * Heart pacemaker * Iron-magnetic surgical clips * Any metallic foreign body in the eye or brain Other criteria (all participants) * Significant history of neurological or psychiatric disorders * Ongoing medication that may affect cognitive performances * Sensory deficit that may interfere with the experimental design (e.g. uncorrected visual impairment) * Lack of sufficient cooperation during the cognitive tasks * Persons under major legal protection and/or deprived of liberty Other criteria (control participants) \- Global cognitive impairment attested by Mattis Dementia Rating Scale or Mini-Mental State Examination, according to available normative data Other criteria (AD-MCI participants) * 7 items modified Hachinski ischemic score \> 2 (Hachinski et al., 2012) * Dementia (McKahn, et al., 2011)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of recognition memory accuracy measures under the familiarity condition as compared with the novel condition in the AD-MCI group | 3 months |
| Significant effect of the familiarity vs novelty condition on the pattern of % BOLD signal change in across the brain in the AD-MCI group | 3 months |
Secondary
| Measure | Time frame |
|---|---|
| Significant group effect on the pattern of % BOLD signal change in across the brain | 3 months |
| Predictive validity of the brain % BOLD signal change pattern for participants clinical status (i.e. controls vs. AD-MCI) | 3 months |
| Significant interaction between the kind of familiarity condition (i.e. novel, experimental or pre-experimental) and the estimates of recognition memory processes efficiency (i.e. respective contributions of recollection and familiarity, % correct) | 3 months |
Countries
France
Outcome results
None listed