Post-transplant Cancer Incidence and Survival in Patients With or Without Pre-transplant Cancer

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02491580

Enrollment

2370

Registered

2015-07-08

Start date

2014-10-31

Completion date

2015-06-30

Last updated

2015-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Failure, Neoplasms

Brief summary

Patients with previous malignancies have increasingly been accepted for renal transplantation. However, post-transplant malignancy risk and survival rates of these patients are unknown. Our aim was to assess if previous malignancies pose an unnecessarily high risk of post-transplant malignant tumours and if the organs as a resource are too limited for investment in this patient group.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Kidney transplanted patients from January 1982 through December 2013 with or without a pre transplant cancer.

Exclusion criteria

* Simultaneous kidney+pancreas transplantation. * Islet cell transplanted patients * Undiagnosed malignancies at the time of transplantation * Death within a week after transplantation * First transplantation at another hospital

Design outcomes

Primary

Measure	Time frame
Incidence of post-transplant cancer	Up to 33 years starting in January 1982.

Secondary

Measure	Time frame
Patient survival	Up to 33 years starting in January 1982.
Cancer-induced mortality	Up to 33 years starting in January 1982.

Other

Measure	Time frame
Graft survival	Up to 33 years starting in January 1982.

Countries

Sweden

Outcome results