Non-small Cell Lung Cancer
Conditions
Keywords
PET scan, FAZA, F-Miso, hypoxia, lung cancer
Brief summary
The purpose of the study is to compare the intratumoral biodistribution of FAZA and F-miso in patients with non-small cell lung cancer and correlate the results of PET scans with immunohistochemistry.
Detailed description
The aim of the study is to compare the biodistribution of the two tracers specific for hypoxia in patients with non-small cell lung cancer. Two PET scans will be performed with FAZA and F-Miso tracers. The time between these twi PET scans will be 24 hours. another 24 hours after the late PET scan, the surgery will be done and a piece of tumor will be collected. Piece of tumor will be analysed by immunohistochemistry for hypoxia markers. The results of immunohistochemistry will be correlated with the biodistribution of the two tracers.
Interventions
DEVICEMiso PET scan
2 PET scans will be performed before surgery : the first one with F-Miso tracer and the second, 24 hours later, with FAZA tracer
DEVICEFAZA PET scan
2 PET scans will be performed before surgery : the first one with FAZA tracer and the second, 24 hours later, with F-Miso tracer
Sponsors
Centre Henri Becquerel
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male or female * More than 18 years old * Patient with non-small cell lung cancer (histologically proved) * PS inferior or equal to 1 (good general state) * Patient must have surgery for their non-small cell lung cancer * Stage of tumor Superior or equal to 2a without metastasis * Tumoral fixation with 18-FDG-PET superior to mediastinal background noise * Written inform consent
Exclusion criteria
* Histology other than primitive non-small cell lung cancer * In situ form at the histological study * Patient without evaluable target * No fixation on the pretherapeutic FDG-PET scan * PS Superior or equal to 2 * neoplastic disease (less than 2 years or progressive) * Pregnant woman or child-bearing * Patient Under guardianship or curators
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of hypoxia with FAZA and F-Miso tracer | one year | SUV max, SUV mean and SUV peak were calculated for FAZA PET and Fmiso PET and will be correlated with results of immunohistochemistry |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| overall survival | one year | time between inclusion and the death whatever the cause |
| disease-free survival | one year | time between inclusion and the progression or death |
Countries
France
Outcome results
None listed