Valvular Heart Disease
Conditions
Brief summary
One of the most important factor that affects the post op complication of the cardiac surgery is systemic inflammation. Valvular heart surgery requires cardiopulmonary bypass and cardioplegic arrest, which can arouse the ischemic/reperfusion injury causing myocardial damage and inflammatory response. These myocardial damage and inflammatory response can cause multi-organ failure or even death.
Detailed description
One of the most important factor that affects the post op complication of the cardiac surgery is systemic inflammation. Valvular heart surgery requires cardiopulmonary bypass and cardioplegic arrest, which can arouse the ischemic/reperfusion injury causing myocardial damage and inflammatory response. These myocardial damage and inflammatory response can cause multi-organ failure or even death. High-mobility group protein B1 (HMGB1) is a protein which is encoded by the HMGB1 gene in human. HMGB1 is secreted by immune cells (like macrophages, monocytes and dendritic cells). Activated macrophages and monocytes secrete HMGB1 as a cytokine mediator of Inflammation. There are many studies suggesting the relationship between HMGB1 and acute coronary syndrome, myocardial ischemic/reperfusion injury, atherosclerosis, heart failure and other cardiac disease as a marker for inflammatory response. However, there are no other study evaluating HMGB1 as a prognostic factor after valvular surgery, so far.
Interventions
PROCEDUREBlood sampling
Blood sampling 5ml
Sponsors
Yonsei University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age ≥ 20 * patients undergoing aortic valve surgery or more than single valve surgery
Exclusion criteria
* age \< 20 * patients undergoing single mitral valve surgery * history of open heart surgery * emergency surgery * history of steroid medication * infective disease and/or malignant tumor * coronary artery bypass surgery or aortic replacement surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| concentration of HMGB1 | collect blood sample right before the surgery after induction of anesthesia | The relationship between concentration of HMGB1 and post op prognosis in patients undergoing valvular heart surgery |
Countries
South Korea
Outcome results
None listed