Pain, Postoperative
Conditions
Keywords
dexmedetomidine, magnesium sulphate
Brief summary
The study will conduct to compare the efficacy of Magnesium sulphate & dexmedetomidine used as adjuvants to bupivacaine in caudal block to provide intra-operative anesthesia as well as post -operative analgesia in pediatric patients.
Detailed description
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Interventions
DRUGDexmedetomidine
Dexmedetomidine 1 μg/ kg
DRUGMagnesium Sulphate
Magnesium Sulphate 50 mg
DRUGBupivacaine
1ml/kg of 0.25%of bupivacaine
DRUGDexmedetomidine + Magnesium Sulphate + Bupivacaine
Dexmedetomidine 1 μg/ kg + Magnesium Sulphate 50 mg + 1ml/kg of 0.25%of bupivacaine
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
6 Months to 6 Years
Healthy volunteers
No
Inclusion criteria
* Healthy male and female children, ASA I and II,Aged 6 months to 6 years, , undergoing elective surgical procedures expected to last more than 90 min, and scheduled to receive general anesthesia combined with caudal extradural block
Exclusion criteria
* Allergy to local anesthetics,coagulation disorders, infection at site of injection, anatomic abnormalities and congenital anomalies like spina bifid, ASA III or higher, Parental refusal and the current use of Calcium Channel Blockers or Medication that may affect the neurologic system
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to first analgesic requirement | 24 hours | The time from end of surgery to the first requirement of postoperative analgesia |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative sedation scores | 24 hours | Level of sedation was recorded throughout the post-anesthesia care unit stay at 15-minute time intervals |
Countries
Egypt
Contacts
Primary ContactJehan A Sayed, MD
Backup Contactmohamed amir, MD
Outcome results
None listed