Oxytocin Infusion vs. Spontaneous Follow-up for Third-stage of Labor After Second-trimester Abortion

Oxytocin Infusion vs. Spontaneous Follow-up for Third-stage Management After Second-trimester Abortion: A Randomized Clinical Trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02485444

Enrollment

160

Registered

2015-06-30

Start date

2015-06-08

Completion date

2016-06-10

Last updated

2023-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abortion, Induced, Labor Stage, Third/Drug Effects, Oxytocin/Administration & Dosage, Pregnancy Trimester, Second

Brief summary

This study compares oxytocin infusion to spontaneous follow-up for third-stage of labor at induced mid-trimester abortions. Patients will be randomized to oxytocin infusion or observation with no pharmacologic intervention. Primary outcome of the study is complete abortion rate within two hours of fetal delivery.

Interventions

DRUGOxytocin

20 IU oxytocin in 500 ml normal saline will be infused 100 ml/h i.v. after fetus is delivered

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

17 Years to 45 Years

Healthy volunteers

Inclusion criteria

-Women who had mid-trimester termination of pregnancy between 13-24 gestational weeks

Exclusion criteria

* If fetus and placenta expelled together * Obstetrical haemorrhage needs intervention * Known prostaglandin allergy

Design outcomes

Primary

Measure	Time frame	Description
Complete abortion rate	within 5 minute after placenta delivered	expulsion of placenta completely without an instrumental assistance within two hours after delivery of fetus

Secondary

Measure	Time frame	Description
Blood loss estimated by gravimetric method	within 10 minutes after delivery of placenta	blood loss will be estimated by gravimetric method
Transfusion rate	Within 7 days of hospitalization	number of packed red cell units transfused
Change in hemoglobin measured by difference in hemoglobin before and 24-hour after abortion	24 hours after delivery of placenta	Difference in hemoglobin before and 24-hour after abortion
Placenta delivery time measured by time elapsed until the delivery of the placenta from the delivery of foetus	5 minute after delivery of placenta	The time elapsed until the delivery of the placenta from the delivery of foetus

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026