Acute Ischemic Stroke, Cerebral Small Vessel Diseases, Intracranial Arteriosclerosis
Conditions
Keywords
AIS, ICAS, CSVD
Brief summary
Our study aims to explore the value of new imaging technique package in predicting early neurological deterioration (END) as well as 90-day unfavorable outcome in patients with acute ischaemic stroke.
Detailed description
1. Patients with acute ischemic stroke within 4.5-72h after onset were prospectively enrolled in our study and underwent standardized clinical and new imaging technique package assessment. 2. New imaging technique package mainly includes conventional cranial MRI （T1,T2,T2 FLAIR,DWI, and ADC), cranial magnetic resonance angiography (MRA), and intracranial vessel wall imaging (High-Resolution Magnetic Resonance Imaging,HRMRI) as well as susceptibility weighted imaging (SWI). 3. The neurofunctional fluctuation during hospitalization as well as 90-day outcomes were carefully assessed. Patients were followed up for 90-days after stroke onset. 4. Our study aims to explore the value of new imaging technique package in predicting early neurological deterioration (END) as well as 90-day unfavorable outcome in patients with acute ischaemic stroke.
Interventions
None listed
Sponsors
Peking Union Medical College Hospital
The Third Medical Center of Chinese PLA General Hospital
Army Medical Center of PLA
The General Hospital of Northern Theater Command
Subei People's Hospital of Jiangsu Province
Second Affiliated Hospital, School of Medicine, Zhejiang University
Beijing Jishuitan Hospital
Fujian Medical University Union Hospital
The First Hospital of Jilin University
The First Affiliated Hospital of University of South China
Qilu Hospital of Shandong University
Tangshan Gongren Hospital
Third Affiliated Hospital, Sun Yat-Sen University
Renmin Hospital of Wuhan University
China-Japan Union Hospital, Jilin University
Shanghai Tong Ren Hospital
Wei-Hai Xu
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. patients with ischemic stroke and hospitalized during 4.5-72 hours after onset , confirmed by diffusion weighted imaging (DWI). 2. patients with stable vital signs. 3. patients who have underwent thrombolytic/intravascular therapy are allowed to enroll in the study.
Exclusion criteria
1. patients with absolute/relative contraindication to MRI (including but not confined to metal in the body and claustrophobia). 2. patients who is extremely agitated, and cannot comply with MRI exam. 3. patients who declined the consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| early neurological deterioration within 3 weeks after stroke onset (END-3 weeks) | 3 weeks after stroke onset | END-3 weeks is defined as a significant neuro-functional decline \[increment of the National Institutes of Health Stroke Scale (NIHSS) ≥ 2 points \] within 3 weeks after admission. |
| 90-days prognosis | 90-days after stroke onset | 90-days prognosis included two parts :1) stroke recurrence with new lesion on DWI;2) the modified Ranking Score (mRS) at 90-days after stroke onset. |
Countries
China
Outcome results
None listed