Muscle Metabolic Function in Older Adults With Different Vitamin D Status Before and After Exercise

A Pilot Study Investigating Differences in Muscle Metabolic Function in Individuals Aged 65-75 Years With Different Vitamin D Status Before and After 7-days of Aerobic Training

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02485197

Enrollment

Registered

2015-06-30

Start date

2013-03-31

Completion date

2015-06-30

Last updated

2017-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitamin D Deficiency

Keywords

Muscle Metabolic Function, Vitamin D Status, 25(OH)D, Older Adults

Brief summary

This is a small pilot aerobic training trial designed to examine differences between normal-high and low vitamin D levels and 7-days of aerobic training on local VO2 measured by non-invasive Hybrid Diffuse Optical Spectroscopy.

Interventions

OTHER7 continuous days of aerobic training

For 7 consecutive days, subjects will perform up to 45 minutes of exercise consisting of treadmill walking at a progressive intensity of about 60-65% of their maximum heart rate. This heart rate range is estimated to be below 60% VO2 max.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

65 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* 65-75 years of age

Exclusion criteria

* Currently have or have a history of cardiovascular or pulmonary disease that would preclude the involvement in the performance of exercise. * Uncontrolled diabetes or hypertension. * History of neurological conditions related to spinal derangement, disk disease, peripheral neuropathies, tremor and rigidity * History of leg/hip trauma, inflammation, infection rhabdomyolysis, or leg surgery in the past 3 months * Have a diagnosis of osteoporosis (as determined by DXA) * Participated in a resistance or aerobic training program in the last 3 months * Engage in more than 1 hr/week of vigorous activity * Body mass index \>29 * On hormone replacement therapy

Design outcomes

Primary

Measure	Time frame	Description
Muscle VO2 consumption	Up to 3 months	The objective is to examine the difference in gastrocnemius VO2 consumption in individuals that either have normal-high or low 25(OH)D and are undergoing 7-days of a treadmill training program.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026