Healthy
Conditions
Keywords
Subjective Effects, Alcohol, Amphetamine, THC, Personality
Brief summary
The purpose of this study is to examine whether individual differences in acute responses to drugs co-vary across three drugs from different drug classes: alcohol, amphetamine and delta-9-tetrahydrocannabinol (THC). The investigators hypothesize that individuals who experience greater rewarding effects from one drug will also experience more rewarding effects from the other drugs.
Detailed description
Here, the investigators aim to investigate whether individuals exhibit similar responses to three different drugs from different classes. This study used a within-subjects design (total N = 24). All subjects received alcohol, amphetamine and delta-9-tetrahydrocannabinol (THC) in a double-blind, double-dummy fashion. Subjects completed six sessions wherein they received either alcohol, amphetamine, or THC, or corresponding placebos, on separate days. Subjects completed questionnaires about mood, general drug effects, and specific drug effects.
Interventions
DRUGTHC
This is a within-subjects, double-blind, placebo controlled design. We administered oral THC to healthy volunteers to measure their subjective response, which we later compared to their responses to two other drugs.
DRUGAMP
This is a within-subjects, double-blind, placebo controlled design. We administered AMP to healthy volunteers to measure their subjective response, which we later compared to their responses to two other drugs.
DRUGALC
This is a within-subjects, double-blind, placebo controlled design. We administered alcohol to healthy volunteers to measure their subjective response, which we later compared to their responses to two other drugs.
DRUGPlacebo capsules
This is a within-subjects, double-blind, placebo controlled design. We administered size 00 gelatin capsules containing dextrose to healthy volunteers as a control for when they received either amphetamine or THC.
DRUGPlacebo beverage
This is a within-subjects, double-blind, placebo controlled design. We administered a drink containing cranberry juice plus 1% alcohol added as a taste mask.
Sponsors
University of Chicago
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* English fluency * High school education * BMI between 19 and 26 * Individuals who report drinking at least 4 alcoholic drinks on one occasion in the past month
Exclusion criteria
* individuals with a medical condition contraindicating study participation, as determined by our physician * individuals regularly using any contraindicated medications * individuals with current dependence on any drug or past dependence on alcohol, marijuana or stimulants * individuals with a past year DSM-IV Axis I mood, anxiety, eating, or psychotic disorder * women who are pregnant, nursing, or planning to become pregnant in the next 3 months * individuals who drink more than 10 alcoholic drinks per week * individuals who currently use i) any illicit drug weekly or more frequently, ii) stimulant prescription drugs, iii) more than 10 cigarettes per week, and iv) more than 3 cups of coffee per day
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | Measured 15 minutes prior to capsule administration and 30 minutes after capsule administration and before drink administration | Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 30 minutes after capsule administration and before drink administration. Baseline was measure 15 minutes prior to capsule administration. |
| Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | Measured 15 minutes prior to capsule administration and 30 minutes after drink administration. | Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 30 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. |
| Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | Measured 15 minutes prior to capsule administration and 90 minutes after drink administration. | Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 90 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. |
| Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | Measured 15 minutes prior to capsule administration and 120 minutes after drink administration. | Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 120 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. |
| Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | Measured 15 minutes prior to capsule administration and 150 minutes after drink administration. | Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 150 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. |
| Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | Measured 15 minutes prior to capsule administration and 180 minutes after drink administration. | Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 180 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. |
| Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | Measured 15 minutes prior to capsule administration and 210 minutes after drink administration. | Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 210 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. |
| Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | Measured 15 minutes prior to capsule administration and 30 minutes after capsule administration and before drink administration | Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects. The change in ARCI was assessed by the difference in measurements between baseline and 30 minutes after capsule administration and before drink administration. Baseline was measure 15 minutes prior to capsule administration. |
| Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | Measured 15 minutes prior to capsule administration and 30 minutes after drink administration | Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects. The change in ARCI was assessed by the difference in measurements between baseline and 30 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. |
| Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | Measured 15 minutes prior to capsule administration and 90 minutes after drink administration | Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects. The change in ARCI was assessed by the difference in measurements between baseline and 90 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. |
| Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | Measured 15 minutes prior to capsule administration and 120 minutes after drink administration | Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects.The change in ARCI was assessed by the difference in measurements between baseline and 120 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. |
| Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | Measured 15 minutes prior to capsule administration and 150 minutes after drink administration | Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects.The change in ARCI was assessed by the difference in measurements between baseline and 150 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. |
| Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | Measured 15 minutes prior to capsule administration and 180 minutes after drink administration | Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects.The change in ARCI was assessed by the difference in measurements between baseline and 180 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. |
| Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | Measured 15 minutes prior to capsule administration and 210 minutes after drink administration | Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects.The change in ARCI was assessed by the difference in measurements between baseline and 210 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. |
Participant flow
Recruitment details
Healthy social drinkers were recruited from the Chicago area through flyers and online advertisements, from June 2013 through February 2014.
Participants by arm
| Arm | Count |
|---|---|
| Healthy Adult Volunteers All healthy adult volunteers completed a 6 session within-subject, double-blind, placebo-controlled trial. At three of these sessions, they received one of three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At each session, they received a capsule and a drink. At the amphetamine drug session, they received a capsule containing d-amphetamine and a placebo beverage. At the THC drug session, they received a capsule containing THC and a placebo beverage. At the alcohol drug session they received a placebo capsule and a beverage containing alcohol. At the three matched placebo sessions, both the capsule and the beverage were placebo. | 28 |
| Total | 28 |
Withdrawals & dropouts
| Period | Reason | FG000 |
|---|---|---|
| Overall Study | expected drug side effect | 1 |
| Overall Study | Withdrawal by Subject | 3 |
Baseline characteristics
| Characteristic | Healthy Adult Volunteers |
|---|---|
| Age, Continuous | 24.6 years STANDARD_DEVIATION 2.8 |
| Sex: Female, Male Female | 16 Participants |
| Sex: Female, Male Male | 12 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 1 / 28 |
| serious Total, serious adverse events | 0 / 28 |
Outcome results
Primary
Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion
Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 120 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.
Time frame: Measured 15 minutes prior to capsule administration and 120 minutes after drink administration.
Population: Participants who completed all sessions
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ High | 18.88 units on a scale | Standard Deviation 21.43 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Like | 43.75 units on a scale | Standard Deviation 36.08 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Feel | 27.08 units on a scale | Standard Deviation 22.38 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ More | 45.38 units on a scale | Standard Deviation 34.86 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Dislike | 11.92 units on a scale | Standard Deviation 19.56 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Like | 23.79 units on a scale | Standard Deviation 25.61 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ High | 29.38 units on a scale | Standard Deviation 25.77 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Feel | 43.92 units on a scale | Standard Deviation 24.18 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ More | 17.5 units on a scale | Standard Deviation 27.95 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Dislike | 44.92 units on a scale | Standard Deviation 31.37 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Like | 18 units on a scale | Standard Deviation 27.26 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ High | 21.96 units on a scale | Standard Deviation 30.06 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ More | 9.92 units on a scale | Standard Deviation 18.06 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Dislike | 19.63 units on a scale | Standard Deviation 27.21 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Feel | 24.08 units on a scale | Standard Deviation 29.28 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Dislike | 13.38 units on a scale | Standard Deviation 22.39 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Feel | 11.92 units on a scale | Standard Deviation 14.26 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Like | 7.04 units on a scale | Standard Deviation 13.9 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ High | 5.04 units on a scale | Standard Deviation 8.12 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ More | 3.13 units on a scale | Standard Deviation 5.53 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ High | 5.08 units on a scale | Standard Deviation 11.2 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Feel | 7.96 units on a scale | Standard Deviation 14.08 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ More | 6.54 units on a scale | Standard Deviation 15.59 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Like | 4.83 units on a scale | Standard Deviation 11.49 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Dislike | 11.08 units on a scale | Standard Deviation 23.89 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Feel | 7.88 units on a scale | Standard Deviation 14.65 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ High | 4.83 units on a scale | Standard Deviation 10.45 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Like | 8.67 units on a scale | Standard Deviation 16.86 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ More | 9.88 units on a scale | Standard Deviation 19.63 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion | DEQ Dislike | 8.88 units on a scale | Standard Deviation 18.69 |
Primary
Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration
Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 150 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.
Time frame: Measured 15 minutes prior to capsule administration and 150 minutes after drink administration.
Population: Participants who completed all sessions
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ High | 16.33 units on a scale | Standard Deviation 18.68 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Like | 39.5 units on a scale | Standard Deviation 34.58 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Feel | 19.79 units on a scale | Standard Deviation 17.72 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ More | 44.08 units on a scale | Standard Deviation 34.63 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Dislike | 11.25 units on a scale | Standard Deviation 20.64 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Like | 21.33 units on a scale | Standard Deviation 24.74 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ High | 20.46 units on a scale | Standard Deviation 23.7 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Feel | 30.83 units on a scale | Standard Deviation 22.52 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ More | 12.58 units on a scale | Standard Deviation 24.39 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Dislike | 40.75 units on a scale | Standard Deviation 32.31 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Like | 11.71 units on a scale | Standard Deviation 19.22 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ High | 14.75 units on a scale | Standard Deviation 20.27 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ More | 9.38 units on a scale | Standard Deviation 18.95 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Dislike | 17.79 units on a scale | Standard Deviation 26.78 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Feel | 18.63 units on a scale | Standard Deviation 25.28 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Dislike | 8.09 units on a scale | Standard Deviation 21.8 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Feel | 5.83 units on a scale | Standard Deviation 10.72 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Like | 6.74 units on a scale | Standard Deviation 14.88 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ High | 2.87 units on a scale | Standard Deviation 4.48 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ More | 2.87 units on a scale | Standard Deviation 10.55 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ High | 2.13 units on a scale | Standard Deviation 4.83 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Feel | 4.63 units on a scale | Standard Deviation 10.48 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ More | 5.04 units on a scale | Standard Deviation 12.75 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Like | 2.42 units on a scale | Standard Deviation 6.76 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Dislike | 4.29 units on a scale | Standard Deviation 13.84 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Feel | 4.63 units on a scale | Standard Deviation 7.8 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ High | 1.96 units on a scale | Standard Deviation 4.56 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Like | 4.96 units on a scale | Standard Deviation 14.48 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ More | 6.21 units on a scale | Standard Deviation 15.19 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration | DEQ Dislike | 6.42 units on a scale | Standard Deviation 15.69 |
Primary
Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration
Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 180 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.
Time frame: Measured 15 minutes prior to capsule administration and 180 minutes after drink administration.
Population: Participants who completed all sessions
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ High | 11.67 units on a scale | Standard Deviation 15.29 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Like | 31.08 units on a scale | Standard Deviation 34.86 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Feel | 16.13 units on a scale | Standard Deviation 17.06 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ More | 38.38 units on a scale | Standard Deviation 34.54 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Dislike | 11.54 units on a scale | Standard Deviation 25.17 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Like | 9.04 units on a scale | Standard Deviation 14.29 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ High | 14.13 units on a scale | Standard Deviation 19.36 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Feel | 22.21 units on a scale | Standard Deviation 19.71 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ More | 7.0 units on a scale | Standard Deviation 19.77 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Dislike | 29.5 units on a scale | Standard Deviation 34.28 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Like | 7.33 units on a scale | Standard Deviation 15.82 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ High | 11.79 units on a scale | Standard Deviation 18.36 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ More | 10.04 units on a scale | Standard Deviation 18.61 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Dislike | 16.13 units on a scale | Standard Deviation 28.42 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Feel | 15.67 units on a scale | Standard Deviation 24.63 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Dislike | 4.25 units on a scale | Standard Deviation 17.24 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Feel | 3.5 units on a scale | Standard Deviation 8.548 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Like | 2.54 units on a scale | Standard Deviation 11.23 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ High | 1.63 units on a scale | Standard Deviation 4.92 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ More | 2.46 units on a scale | Standard Deviation 10.99 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ High | 1.25 units on a scale | Standard Deviation 3.3 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Feel | 2.08 units on a scale | Standard Deviation 5.01 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ More | 4.04 units on a scale | Standard Deviation 12.22 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Like | 1.75 units on a scale | Standard Deviation 7.56 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Dislike | 4.29 units on a scale | Standard Deviation 16.8 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Feel | 2.54 units on a scale | Standard Deviation 4.59 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ High | 1.04 units on a scale | Standard Deviation 3.3 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Like | 4.0 units on a scale | Standard Deviation 12.47 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ More | 5.04 units on a scale | Standard Deviation 12.89 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration | DEQ Dislike | 4.63 units on a scale | Standard Deviation 13.65 |
Primary
Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration
Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 210 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.
Time frame: Measured 15 minutes prior to capsule administration and 210 minutes after drink administration.
Population: Participants who completed all sessions
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ High | 6.25 units on a scale | Standard Deviation 9.88 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Like | 18.38 units on a scale | Standard Deviation 31.38 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Feel | 11.08 units on a scale | Standard Deviation 16.71 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ More | 32.5 units on a scale | Standard Deviation 31.84 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Dislike | 8.54 units on a scale | Standard Deviation 24.16 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Like | 7.33 units on a scale | Standard Deviation 14.62 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ High | 9.21 units on a scale | Standard Deviation 15.84 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Feel | 12.88 units on a scale | Standard Deviation 15.88 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ More | 4.54 units on a scale | Standard Deviation 17.72 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Dislike | 22.71 units on a scale | Standard Deviation 30.79 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Like | 4.88 units on a scale | Standard Deviation 10.41 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ High | 4.96 units on a scale | Standard Deviation 11.02 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ More | 8.79 units on a scale | Standard Deviation 17.04 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Dislike | 6.83 units on a scale | Standard Deviation 15.46 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Feel | 5.79 units on a scale | Standard Deviation 10.91 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Dislike | 7.46 units on a scale | Standard Deviation 23.16 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Feel | 2.17 units on a scale | Standard Deviation 5.74 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Like | 1.96 units on a scale | Standard Deviation 7.04 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ High | 0.33 units on a scale | Standard Deviation 1.05 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ More | 2.25 units on a scale | Standard Deviation 8.19 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ High | 0.83 units on a scale | Standard Deviation 1.76 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Feel | 0.96 units on a scale | Standard Deviation 2.74 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ More | 3.83 units on a scale | Standard Deviation 12.09 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Like | 0.25 units on a scale | Standard Deviation 0.74 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Dislike | 1.29 units on a scale | Standard Deviation 3.82 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Feel | 1.08 units on a scale | Standard Deviation 2.75 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ High | 0.42 units on a scale | Standard Deviation 1.32 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Like | 4.38 units on a scale | Standard Deviation 13.73 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ More | 6.17 units on a scale | Standard Deviation 14.65 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration | DEQ Dislike | 4.54 units on a scale | Standard Deviation 15.14 |
Primary
Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration
Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 30 minutes after capsule administration and before drink administration. Baseline was measure 15 minutes prior to capsule administration.
Time frame: Measured 15 minutes prior to capsule administration and 30 minutes after capsule administration and before drink administration
Population: Participants who completed all sessions
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ High | 3.29 units on a scale | Standard Deviation 6.06 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Like | 16.08 units on a scale | Standard Deviation 27.47 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Feel | 4.79 units on a scale | Standard Deviation 7.22 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ More | 14.21 units on a scale | Standard Deviation 25.26 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Dislike | 4.21 units on a scale | Standard Deviation 9.43 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Like | 18.67 units on a scale | Standard Deviation 28.81 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ High | 8.83 units on a scale | Standard Deviation 16.31 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Feel | 12.83 units on a scale | Standard Deviation 18.78 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ More | 13.5 units on a scale | Standard Deviation 25.24 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Dislike | 11.71 units on a scale | Standard Deviation 20.35 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Like | 11.75 units on a scale | Standard Deviation 21.84 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ High | 10.58 units on a scale | Standard Deviation 21.85 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ More | 6.54 units on a scale | Standard Deviation 13.71 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Dislike | 12.38 units on a scale | Standard Deviation 23.77 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Feel | 11.08 units on a scale | Standard Deviation 21.09 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Dislike | 10.71 units on a scale | Standard Deviation 18.75 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Feel | 12.17 units on a scale | Standard Deviation 19.9 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Like | 9.0 units on a scale | Standard Deviation 18.42 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ High | 6.96 units on a scale | Standard Deviation 18.44 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ More | 5.63 units on a scale | Standard Deviation 12.59 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ High | 5.5 units on a scale | Standard Deviation 10.43 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Feel | 9.38 units on a scale | Standard Deviation 11.12 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ More | 3.71 units on a scale | Standard Deviation 7.66 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Like | 10.04 units on a scale | Standard Deviation 17.9 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Dislike | 11.0 units on a scale | Standard Deviation 20.6 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Feel | 4.5 units on a scale | Standard Deviation 13.16 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ High | 3.67 units on a scale | Standard Deviation 9.4 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Like | 9.67 units on a scale | Standard Deviation 24.14 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ More | 11.0 units on a scale | Standard Deviation 25.32 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration | DEQ Dislike | 0.83 units on a scale | Standard Deviation 2.24 |
Primary
Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration
Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 30 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.
Time frame: Measured 15 minutes prior to capsule administration and 30 minutes after drink administration.
Population: Participants who completed all sessions
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ High | 30.5 units on a scale | Standard Deviation 27.78 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Like | 53.88 units on a scale | Standard Deviation 34.49 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Feel | 43.42 units on a scale | Standard Deviation 29.53 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ More | 42.17 units on a scale | Standard Deviation 35.27 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Dislike | 15.71 units on a scale | Standard Deviation 22.76 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Like | 45.08 units on a scale | Standard Deviation 28.43 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ High | 50.38 units on a scale | Standard Deviation 32.15 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Feel | 76.83 units on a scale | Standard Deviation 20.01 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ More | 24.75 units on a scale | Standard Deviation 32.67 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Dislike | 43.96 units on a scale | Standard Deviation 28.96 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Like | 28.75 units on a scale | Standard Deviation 30.05 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ High | 31.75 units on a scale | Standard Deviation 35 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ More | 17.46 units on a scale | Standard Deviation 25.18 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Dislike | 25.63 units on a scale | Standard Deviation 35.03 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Feel | 38.25 units on a scale | Standard Deviation 33.45 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Dislike | 17.71 units on a scale | Standard Deviation 23.32 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Feel | 21.58 units on a scale | Standard Deviation 19.52 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Like | 16.63 units on a scale | Standard Deviation 22.89 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ High | 12.54 units on a scale | Standard Deviation 18.09 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ More | 10.96 units on a scale | Standard Deviation 19.14 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ High | 11.5 units on a scale | Standard Deviation 21.8 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Feel | 17.83 units on a scale | Standard Deviation 22.56 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ More | 10.0 units on a scale | Standard Deviation 18.32 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Like | 14.38 units on a scale | Standard Deviation 20.78 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Dislike | 16.68 units on a scale | Standard Deviation 26.83 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Feel | 18.63 units on a scale | Standard Deviation 20.69 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ High | 12.96 units on a scale | Standard Deviation 20.22 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Like | 25.29 units on a scale | Standard Deviation 28.76 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ More | 18.96 units on a scale | Standard Deviation 28.97 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration | DEQ Dislike | 15.79 units on a scale | Standard Deviation 20.66 |
Primary
Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration
Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 90 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.
Time frame: Measured 15 minutes prior to capsule administration and 90 minutes after drink administration.
Population: Participants who completed all sessions
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ High | 27.92 units on a scale | Standard Deviation 24.57 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Like | 55.67 units on a scale | Standard Deviation 31.45 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Feel | 34.92 units on a scale | Standard Deviation 24.75 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ More | 50.21 units on a scale | Standard Deviation 36.06 |
| AMP Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Dislike | 16.54 units on a scale | Standard Deviation 21.6 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Like | 29.92 units on a scale | Standard Deviation 28.57 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ High | 41.83 units on a scale | Standard Deviation 30.74 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Feel | 61.21 units on a scale | Standard Deviation 24.02 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ More | 25.88 units on a scale | Standard Deviation 35.11 |
| ALC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Dislike | 50.46 units on a scale | Standard Deviation 26.47 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Like | 20.08 units on a scale | Standard Deviation 26.32 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ High | 29.21 units on a scale | Standard Deviation 32.78 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ More | 16.54 units on a scale | Standard Deviation 23.69 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Dislike | 23.25 units on a scale | Standard Deviation 29.72 |
| THC Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Feel | 31.54 units on a scale | Standard Deviation 31.41 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Dislike | 17.54 units on a scale | Standard Deviation 26.16 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Feel | 16.46 units on a scale | Standard Deviation 18.97 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Like | 10.42 units on a scale | Standard Deviation 18.22 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ High | 6.83 units on a scale | Standard Deviation 12.47 |
| AMP Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ More | 6.54 units on a scale | Standard Deviation 15.33 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ High | 7.25 units on a scale | Standard Deviation 13.5 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Feel | 12.75 units on a scale | Standard Deviation 18.74 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ More | 7.71 units on a scale | Standard Deviation 16.59 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Like | 11.38 units on a scale | Standard Deviation 19.35 |
| ALC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Dislike | 15.33 units on a scale | Standard Deviation 24.85 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Feel | 13.17 units on a scale | Standard Deviation 19.05 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ High | 7.58 units on a scale | Standard Deviation 12.65 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Like | 13.25 units on a scale | Standard Deviation 22.87 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ More | 12.88 units on a scale | Standard Deviation 21.88 |
| THC Placebo Arm | Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration | DEQ Dislike | 15.96 units on a scale | Standard Deviation 24.91 |
Primary
Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration
Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects.The change in ARCI was assessed by the difference in measurements between baseline and 120 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.
Time frame: Measured 15 minutes prior to capsule administration and 120 minutes after drink administration
Population: Participants who completed all sessions
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC A | 2.17 units on a scale | Standard Deviation 2.06 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC MBG | 3.33 units on a scale | Standard Deviation 4.35 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC LSD | 0.38 units on a scale | Standard Deviation 1.93 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC BG | 1.67 units on a scale | Standard Deviation 2.12 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC PCAG | -1.08 units on a scale | Standard Deviation 2.02 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC M | 1.83 units on a scale | Standard Deviation 2.46 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC MBG | -1.13 units on a scale | Standard Deviation 2.13 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC BG | -2.04 units on a scale | Standard Deviation 1.73 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC M | 1.08 units on a scale | Standard Deviation 1.56 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC A | -0.33 units on a scale | Standard Deviation 1.34 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC LSD | 0.79 units on a scale | Standard Deviation 1.28 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC PCAG | 5.46 units on a scale | Standard Deviation 2.93 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC M | 1.42 units on a scale | Standard Deviation 2.04 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC PCAG | 2.88 units on a scale | Standard Deviation 3.49 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC BG | -1.54 units on a scale | Standard Deviation 1.64 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC LSD | 1 units on a scale | Standard Deviation 2.83 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC A | -0.08 units on a scale | Standard Deviation 1.21 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC MBG | -0.96 units on a scale | Standard Deviation 2.6 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC BG | -1 units on a scale | Standard Deviation 1.35 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC MBG | -0.125 units on a scale | Standard Deviation 0.85 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC LSD | -0.13 units on a scale | Standard Deviation 1.15 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC M | 0.25 units on a scale | Standard Deviation 0.85 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC PCAG | 1.71 units on a scale | Standard Deviation 2.65 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC A | -0.17 units on a scale | Standard Deviation 0.7 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC A | -0.71 units on a scale | Standard Deviation 1.37 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC PCAG | 1.63 units on a scale | Standard Deviation 2.76 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC MBG | -1.29 units on a scale | Standard Deviation 2.97 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC LSD | 0.04 units on a scale | Standard Deviation 1.16 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC BG | -0.83 units on a scale | Standard Deviation 1.55 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC M | -0.04 units on a scale | Standard Deviation 0.86 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC BG | -0.38 units on a scale | Standard Deviation 1.58 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC LSD | -0.08 units on a scale | Standard Deviation 0.93 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC PCAG | 1.08 units on a scale | Standard Deviation 1.98 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC M | 0.17 units on a scale | Standard Deviation 0.56 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC MBG | -0.08 units on a scale | Standard Deviation 0.65 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration | ARC A | -0.04 units on a scale | Standard Deviation 0.86 |
Primary
Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration
Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects.The change in ARCI was assessed by the difference in measurements between baseline and 150 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.
Time frame: Measured 15 minutes prior to capsule administration and 150 minutes after drink administration
Population: Participants who completed all sessions
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC A | 2.29 units on a scale | Standard Deviation 2.61 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC MBG | 2.96 units on a scale | Standard Deviation 4.39 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC LSD | 0.5 units on a scale | Standard Deviation 1.59 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC BG | 1.75 units on a scale | Standard Deviation 2.31 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC PCAG | -1 units on a scale | Standard Deviation 1.64 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC M | 1.54 units on a scale | Standard Deviation 1.91 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC M | 0.75 units on a scale | Standard Deviation 1.33 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC LSD | 0.79 units on a scale | Standard Deviation 1.35 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC A | -0.54 units on a scale | Standard Deviation 1.14 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC BG | -2.04 units on a scale | Standard Deviation 1.65 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC PCAG | 5.46 units on a scale | Standard Deviation 2.95 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC MBG | -1.54 units on a scale | Standard Deviation 1.96 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC MBG | -0.96 units on a scale | Standard Deviation 2.39 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC BG | -1.29 units on a scale | Standard Deviation 1.86 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC PCAG | 2.58 units on a scale | Standard Deviation 3.16 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC LSD | 0.58 units on a scale | Standard Deviation 2.22 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC A | -0.17 units on a scale | Standard Deviation 1.63 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC M | 0.83 units on a scale | Standard Deviation 1.83 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC M | 0.22 units on a scale | Standard Deviation 0.74 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC A | -0.13 units on a scale | Standard Deviation 0.69 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC LSD | 0.09 units on a scale | Standard Deviation 1.08 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC BG | -0.43 units on a scale | Standard Deviation 1.31 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC MBG | 0.13 units on a scale | Standard Deviation 0.76 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC PCAG | 0.65 units on a scale | Standard Deviation 2.17 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC M | -0.21 units on a scale | Standard Deviation 0.78 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC LSD | -0.13 units on a scale | Standard Deviation 1.03 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC A | -0.54 units on a scale | Standard Deviation 1.47 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC MBG | -1.25 units on a scale | Standard Deviation 2.88 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC BG | -0.67 units on a scale | Standard Deviation 1.24 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC PCAG | 1.58 units on a scale | Standard Deviation 2.96 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC A | -0.08 units on a scale | Standard Deviation 0.83 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC MBG | -0.08 units on a scale | Standard Deviation 0.88 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC LSD | -0.17 units on a scale | Standard Deviation 0.82 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC BG | -0.42 units on a scale | Standard Deviation 1.28 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC PCAG | 0.79 units on a scale | Standard Deviation 1.79 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration | ARC M | 0.08 units on a scale | Standard Deviation 0.41 |
Primary
Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration
Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects.The change in ARCI was assessed by the difference in measurements between baseline and 180 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.
Time frame: Measured 15 minutes prior to capsule administration and 180 minutes after drink administration
Population: Participants who completed all sessions
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC A | 1.58 units on a scale | Standard Deviation 2.26 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC MBG | 1.92 units on a scale | Standard Deviation 4.03 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC LSD | 0.46 units on a scale | Standard Deviation 1.91 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC BG | 1.13 units on a scale | Standard Deviation 2.15 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC PCAG | -0.46 units on a scale | Standard Deviation 1.93 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC M | 1.21 units on a scale | Standard Deviation 1.59 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC MBG | -1.29 units on a scale | Standard Deviation 1.88 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC BG | -1.5 units on a scale | Standard Deviation 1.47 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC M | 0.08 units on a scale | Standard Deviation 1.02 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC A | -0.75 units on a scale | Standard Deviation 1.19 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC LSD | 0.54 units on a scale | Standard Deviation 1.02 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC PCAG | 3.63 units on a scale | Standard Deviation 3.01 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC M | 0.71 units on a scale | Standard Deviation 1.94 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC PCAG | 2.13 units on a scale | Standard Deviation 3.43 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC BG | -1.29 units on a scale | Standard Deviation 1.78 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC LSD | 0.54 units on a scale | Standard Deviation 1.82 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC A | -0.21 units on a scale | Standard Deviation 1.44 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC MBG | -0.67 units on a scale | Standard Deviation 2.37 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC BG | -0.33 units on a scale | Standard Deviation 1.13 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC MBG | 0.33 units on a scale | Standard Deviation 1.24 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC LSD | 0.04 units on a scale | Standard Deviation 1.04 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC M | 0.13 units on a scale | Standard Deviation 0.68 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC PCAG | 0.21 units on a scale | Standard Deviation 2.5 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC A | -0.04 units on a scale | Standard Deviation 0.91 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC A | -0.33 units on a scale | Standard Deviation 1.69 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC PCAG | 0.71 units on a scale | Standard Deviation 2.73 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC MBG | -1.08 units on a scale | Standard Deviation 3.01 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC LSD | -0.04 units on a scale | Standard Deviation 0.81 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC BG | -0.38 units on a scale | Standard Deviation 1.41 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC M | -0.13 units on a scale | Standard Deviation 0.74 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC BG | -0.29 units on a scale | Standard Deviation 1.2 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC LSD | 0.04 units on a scale | Standard Deviation 0.95 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC PCAG | 0.42 units on a scale | Standard Deviation 1.59 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC M | -0.08 units on a scale | Standard Deviation 0.28 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC MBG | -0.17 units on a scale | Standard Deviation 0.82 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration | ARC A | -0.17 units on a scale | Standard Deviation 1.13 |
Primary
Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration
Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects.The change in ARCI was assessed by the difference in measurements between baseline and 210 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.
Time frame: Measured 15 minutes prior to capsule administration and 210 minutes after drink administration
Population: Participants who completed all sessions
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC A | 1.0 units on a scale | Standard Deviation 1.93 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC MBG | 1.38 units on a scale | Standard Deviation 3.31 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC LSD | 0.63 units on a scale | Standard Deviation 1.79 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC BG | 0.83 units on a scale | Standard Deviation 1.61 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC PCAG | -0.29 units on a scale | Standard Deviation 2.1 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC M | 0.96 units on a scale | Standard Deviation 1.97 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC MBG | -1.17 units on a scale | Standard Deviation 2.08 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC BG | -1.25 units on a scale | Standard Deviation 1.39 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC M | 0.08 units on a scale | Standard Deviation 0.97 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC A | -0.71 units on a scale | Standard Deviation 1.2 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC LSD | 0.33 units on a scale | Standard Deviation 0.92 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC PCAG | 3.17 units on a scale | Standard Deviation 3.17 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC M | 0.21 units on a scale | Standard Deviation 0.72 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC PCAG | 1.04 units on a scale | Standard Deviation 1.76 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC BG | -0.83 units on a scale | Standard Deviation 1.4 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC LSD | 0.54 units on a scale | Standard Deviation 1.22 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC A | -0.46 units on a scale | Standard Deviation 1.06 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC MBG | -0.88 units on a scale | Standard Deviation 1.92 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC BG | -0.17 units on a scale | Standard Deviation 0.82 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC MBG | 0.13 units on a scale | Standard Deviation 1.15 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC LSD | 0.25 units on a scale | Standard Deviation 0.9 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC M | 0 units on a scale | Standard Deviation 0.42 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC PCAG | -0.29 units on a scale | Standard Deviation 1.43 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC A | -0.17 units on a scale | Standard Deviation 0.82 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC A | -0.54 units on a scale | Standard Deviation 1.5 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC PCAG | 0.21 units on a scale | Standard Deviation 2.55 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC MBG | -0.79 units on a scale | Standard Deviation 2.95 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC LSD | 1.67 units on a scale | Standard Deviation 0.87 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC BG | -0.38 units on a scale | Standard Deviation 1.06 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC M | -0.17 units on a scale | Standard Deviation 0.7 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC BG | -0.13 units on a scale | Standard Deviation 1.48 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC LSD | 0.04 units on a scale | Standard Deviation 1.04 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC PCAG | 0.13 units on a scale | Standard Deviation 1.68 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC M | -0.08 units on a scale | Standard Deviation 0.28 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC MBG | 0.04 units on a scale | Standard Deviation 0.86 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration | ARC A | 0.08 units on a scale | Standard Deviation 1.21 |
Primary
Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration
Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects. The change in ARCI was assessed by the difference in measurements between baseline and 30 minutes after capsule administration and before drink administration. Baseline was measure 15 minutes prior to capsule administration.
Time frame: Measured 15 minutes prior to capsule administration and 30 minutes after capsule administration and before drink administration
Population: Participants who completed all sessions
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC A | -0.17 units on a scale | Standard Deviation 0.92 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC MBG | -0.58 units on a scale | Standard Deviation 1.44 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC LSD | 0.13 units on a scale | Standard Deviation 0.85 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC BG | -0.46 units on a scale | Standard Deviation 1.02 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC PCAG | 0.58 units on a scale | Standard Deviation 1.21 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC M | 0.08 units on a scale | Standard Deviation 1.06 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC MBG | -0.29 units on a scale | Standard Deviation 1.27 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC BG | -0.75 units on a scale | Standard Deviation 1.67 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC M | 0.83 units on a scale | Standard Deviation 1.81 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC A | 0.25 units on a scale | Standard Deviation 1.33 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC LSD | 0.33 units on a scale | Standard Deviation 0.82 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC PCAG | 1.29 units on a scale | Standard Deviation 2.39 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC M | 0.42 units on a scale | Standard Deviation 1.32 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC PCAG | 2.92 units on a scale | Standard Deviation 2.73 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC BG | -0.79 units on a scale | Standard Deviation 2 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC LSD | 0.38 units on a scale | Standard Deviation 1.69 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC A | -0.04 units on a scale | Standard Deviation 1.16 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC MBG | -0.71 units on a scale | Standard Deviation 1.88 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC BG | -1.17 units on a scale | Standard Deviation 1.52 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC MBG | -0.58 units on a scale | Standard Deviation 0.65 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC LSD | 0.13 units on a scale | Standard Deviation 0.99 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC M | 0.5 units on a scale | Standard Deviation 1.25 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC PCAG | 1.96 units on a scale | Standard Deviation 2.44 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC A | -0.25 units on a scale | Standard Deviation 0.61 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC A | -0.17 units on a scale | Standard Deviation 1.2 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC PCAG | 0.92 units on a scale | Standard Deviation 1.61 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC MBG | -0.67 units on a scale | Standard Deviation 1.46 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC LSD | 0.08 units on a scale | Standard Deviation 0.97 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC BG | -0.92 units on a scale | Standard Deviation 1.21 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC M | 0.33 units on a scale | Standard Deviation 1.05 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC BG | 0.25 units on a scale | Standard Deviation 1.03 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC LSD | -0.17 units on a scale | Standard Deviation 0.64 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC PCAG | 0.42 units on a scale | Standard Deviation 1.02 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC M | 0.42 units on a scale | Standard Deviation 1.18 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC MBG | 0.33 units on a scale | Standard Deviation 1.37 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration | ARC A | 0.54 units on a scale | Standard Deviation 0.88 |
Primary
Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration
Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects. The change in ARCI was assessed by the difference in measurements between baseline and 30 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.
Time frame: Measured 15 minutes prior to capsule administration and 30 minutes after drink administration
Population: Participants who completed all sessions
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC A | 2.88 units on a scale | Standard Deviation 2.8 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC MBG | 3.71 units on a scale | Standard Deviation 4.59 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC LSD | 1.13 units on a scale | Standard Deviation 2.03 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC BG | 1.63 units on a scale | Standard Deviation 2.28 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC PCAG | -1 units on a scale | Standard Deviation 1.89 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC M | 3.21 units on a scale | Standard Deviation 2.73 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC MBG | 1.38 units on a scale | Standard Deviation 4.79 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC BG | -0.88 units on a scale | Standard Deviation 3 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC M | 3.42 units on a scale | Standard Deviation 2.22 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC A | 1.92 units on a scale | Standard Deviation 2.64 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC LSD | 2.63 units on a scale | Standard Deviation 2.32 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC PCAG | 3.71 units on a scale | Standard Deviation 4.29 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC M | 2.04 units on a scale | Standard Deviation 2.56 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC PCAG | 2.96 units on a scale | Standard Deviation 3.33 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC BG | -1.38 units on a scale | Standard Deviation 1.64 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC LSD | 1.54 units on a scale | Standard Deviation 2.47 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC A | 0.17 units on a scale | Standard Deviation 0.96 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC MBG | -0.54 units on a scale | Standard Deviation 3.04 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC BG | -0.83 units on a scale | Standard Deviation 1.31 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC MBG | 0 units on a scale | Standard Deviation 1.77 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC LSD | 0.33 units on a scale | Standard Deviation 1.09 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC M | 0.42 units on a scale | Standard Deviation 0.93 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC PCAG | 2.25 units on a scale | Standard Deviation 3.55 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC A | 0 units on a scale | Standard Deviation 0.93 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC A | -0.33 units on a scale | Standard Deviation 1.61 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC PCAG | 1.54 units on a scale | Standard Deviation 3.24 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC MBG | -1.17 units on a scale | Standard Deviation 2.75 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC LSD | 0.29 units on a scale | Standard Deviation 1.12 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC BG | -0.96 units on a scale | Standard Deviation 1.99 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC M | 0.29 units on a scale | Standard Deviation 1.16 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC BG | 0.04 units on a scale | Standard Deviation 1.46 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC LSD | 0.13 units on a scale | Standard Deviation 1.23 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC PCAG | 1.13 units on a scale | Standard Deviation 2.35 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC M | 0.96 units on a scale | Standard Deviation 1.78 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC MBG | 0.88 units on a scale | Standard Deviation 3.26 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration | ARC A | 0.71 units on a scale | Standard Deviation 1.4 |
Primary
Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration
Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects. The change in ARCI was assessed by the difference in measurements between baseline and 90 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.
Time frame: Measured 15 minutes prior to capsule administration and 90 minutes after drink administration
Population: Participants who completed all sessions
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC A | 2.96 units on a scale | Standard Deviation 2.49 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC MBG | 3.67 units on a scale | Standard Deviation 4.86 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC LSD | 1.08 units on a scale | Standard Deviation 1.89 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC BG | 2.17 units on a scale | Standard Deviation 2.39 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC PCAG | -1.21 units on a scale | Standard Deviation 2.17 |
| AMP Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC M | 2.63 units on a scale | Standard Deviation 2.46 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC MBG | -0.38 units on a scale | Standard Deviation 2.45 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC BG | -2.54 units on a scale | Standard Deviation 2.4 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC M | 2.25 units on a scale | Standard Deviation 2.51 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC A | 0.29 units on a scale | Standard Deviation 2.44 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC LSD | 1.79 units on a scale | Standard Deviation 1.93 |
| ALC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC PCAG | 6.21 units on a scale | Standard Deviation 2.92 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC M | 2.04 units on a scale | Standard Deviation 2.63 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC PCAG | 3.54 units on a scale | Standard Deviation 3.68 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC BG | -1.71 units on a scale | Standard Deviation 2.03 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC LSD | 1.42 units on a scale | Standard Deviation 2.69 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC A | 0 units on a scale | Standard Deviation 1.22 |
| THC Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC MBG | -0.83 units on a scale | Standard Deviation 2.55 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC BG | -1.29 units on a scale | Standard Deviation 1.63 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC MBG | -0.29 units on a scale | Standard Deviation 0.86 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC LSD | -0.04 units on a scale | Standard Deviation 0.95 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC M | 0.42 units on a scale | Standard Deviation 0.97 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC PCAG | 2.67 units on a scale | Standard Deviation 2.96 |
| AMP Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC A | -0.33 units on a scale | Standard Deviation 0.76 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC A | -0.58 units on a scale | Standard Deviation 1.28 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC PCAG | 1.92 units on a scale | Standard Deviation 3.22 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC MBG | -1.29 units on a scale | Standard Deviation 2.93 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC LSD | 0.29 units on a scale | Standard Deviation 1.12 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC BG | -1.13 units on a scale | Standard Deviation 1.57 |
| ALC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC M | 0.13 units on a scale | Standard Deviation 0.8 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC BG | -0.67 units on a scale | Standard Deviation 1.46 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC LSD | 0.08 units on a scale | Standard Deviation 0.93 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC PCAG | 1.58 units on a scale | Standard Deviation 1.91 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC M | 0.29 units on a scale | Standard Deviation 0.62 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC MBG | -0.13 units on a scale | Standard Deviation 0.95 |
| THC Placebo Arm | Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration | ARC A | -0.08 units on a scale | Standard Deviation 1.02 |