Comparison of ACT Between Hemochron Jr and ACT Plus

Comparison of Activated Coagulation Time Between Hemochron Jr and ACT Plus During Cardiac Surgery for Patient Using Acute Normovolemic Hemodilution

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02484157

Enrollment

Registered

2015-06-29

Start date

2012-12-31

Completion date

2014-01-31

Last updated

2015-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Disease

Keywords

Whole Blood Coagulation Time, cardiac surgery

Brief summary

This study aimed to compare 2 activated clotting time analysers (Hemochron Jr vs. ACT Plus).

Detailed description

Measurement of activated clotting time (ACT) is a standard method for anticoagulation monitoring. Especially in cardiac surgery, heparin is usually used as anticoagulant and protamine is used to reverse anticoagulation effect at the end of surgery. ACT method defines the time until a clot is formed in a test tube after triggering of internal pathway coagulation using blood activating agents (eg. kaolin). Acute normovolemic hemodilution (ANH) consists of withdrawing patient's blood volume early in the operative period and concurrent infusion of crystalloid or colloid to maintain intravascular volume, and is used in cardiac surgery. ANH is known to affect hemostasis in some studies. Assuming that accurate monitoring of coagulation therapy is important to prevent both thrombotic and hemorrhagic complications, we compared ACT results from 2 analysers (Hemochron Jr and ACT Plus) in patients undergoing cardiac surgery using ANH.

Interventions

DEVICEHemochron

Activated coagulation time was checked serially by Hemochron Jr.

DEVICEACT Plus

Activated coagulation time was checked serially by ACT Plus.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients who underwent cardiac surgery with heparin administration.

Exclusion criteria

* Preoperative hemoglobin under 11g/dL * Weight under 40kg * Preoperative coagulopathy

Design outcomes

Primary

Measure	Time frame
Comparison of activated coagulation time between Hemochron Jr and ACT Plus	During cardiac surgeris (within 8 hours)

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026