Analgesic Effect to Postoperative Pain After Mastectomy: Ultrasound-guided Serratus Anterior Plane Block

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02483923

Enrollment

Registered

2015-06-29

Start date

2015-06-16

Completion date

2016-02-28

Last updated

2018-07-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer

Keywords

serratus anterior block, ultrasound, breast cancer, postoperative pain

Brief summary

Ultrasound guided serratus anterior plane block may decrease acute postoperative pain and consumption of opioid after mastectomy.

Interventions

DRUGUltrasound guided serratus anterior block with ropivacaine

After induction of anesthesia, patients take ultrasound guided serratus anterior plane block with 0.5ml/kg of ropivacaine 0.375%. 30minutes before the end of operation, intravenous patient controlled analgesia (Basal rate 0ml/hr, 0.5mcg/kg of fentanyl, lock-out time 10minutes) is connected to patient.

DRUGintravenous PCA only

same dose of intravenous patient controlled analgesia (Basal rate 0ml/hr, 0.5mcg/kg of fentanyl, lock-out time 10minutes) is connected to patient only.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

1. ASA 1\ 3 2. Age 20\ 80 3. Breast cancer patient twho are scheduled for elective mastectomy

Exclusion criteria

1. Allergy to local anesthetics or contraindication to use of ropivacaine 2. Pregnancy 3. Severe cardiovascular disease 4. Renal failure 5. Liver failure 6. Neurologic and psychologic disease 7. Chronic treatment with analgesics 8. Previous history of mastectomy or thoracic surgery.

Design outcomes

Primary

Measure	Time frame	Description
Total opioid consumption	within 24 hrs after mastectomy	Assessing total opioid consumption (total number of bolus injection and total dose of fentanyl via intravenous patient controlled analgesia) within 24hours after operation finished.

Secondary

Measure	Time frame
Postoperative pain scale (Numeric rating scale 0-10) at PACU	chang from 3,6,12,24 to 48hrs after operation end
Total intraoperative remifentanil consumption(mcg)	within 24 hrs after mastectomy
Additional analgesics requirements (dose/number)	within 24 hrs after mastectomy
incidence and intensity of postoperative nausea and vomiting(NRS:0-10)	within 24 hrs after mastectomy
Total hospital staying time	within 24 hrs after mastectomy

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026