Subarachnoid Hemorrhage
Conditions
Keywords
Blood Transfusion
Brief summary
The purpose of this study is to determine the feasibility of conducting a large trial examining the effect on clinical outcome of a liberal red blood cell (RBC) transfusion strategy compared to a restrictive strategy (usual care) in patients with aneurysmal subarachnoid hemorrhage (SAH).
Interventions
OTHERLiberal Red Blood Cell Transfusion Strategy
RBC Transfusion strategy with hemoglobin trigger of 100g/L
OTHERRestrictive Red Blood Cell Transfusion Strategy
Optional RBC Transfusion with hemoglobin trigger of \<=80g/L
Sponsors
Ottawa Hospital Research Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age ≥18 years old at time of presentation 2. First ever episode aneurysmal SAH 3. Confirmed aneurysmal SAH diagnosis: as confirmed by treating Neurosurgeon or Neuro-interventionalist and supported by blood in subarachnoid space (demonstrated on cranial imaging or cerebrospinal fluid positive for xanthochromia) that is the result of a ruptured saccular aneurysm (confirmed by cranial imaging - cranial topography or magnetic resonance imaging angiography or catheter angiogram) 4. Incident hemoglobin ≤100g/L within 14 days following SAH (defined by first day of hospital presentation)
Exclusion criteria
1. Physician and or family decision to withdraw/withhold critical care at time of enrolment 2. Active bleeding with hemodynamic instability at time of enrolment 3. Patients with contra-indication or known objection to blood transfusions 4. SAH due to causes other than saccular aneurysm rupture including mycotic, traumatic and dissecting aneurysms, and aneurysms associated with arteriovenous malformations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Randomization Rate | 12 months |
Countries
Canada
Outcome results
None listed