A Study Comparing Radiofrequency Ablation and Hepatic Resection for Hepatocellular Carcinoma

A Prospective Randomized Study to Compare the Efficacy of Radiofrequency Ablation and Hepatic Resection as a Primary Treatment for Single Small Hepatocellular Carcinoma

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02482909

Enrollment

Registered

2015-06-26

Start date

2005-07-31

Completion date

2013-07-31

Last updated

2015-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carcinoma, Hepatocellular

Brief summary

The purpose of this prospective randomized study is to compare the efficacy and safety of radiofrequency ablation and hepatic resection for small hepatocellular carcinomas with very homogeneous underlying conditions.

Interventions

PROCEDUREHepatic resection

Anatomical surgical resection of the liver including the tumor

PROCEDURERadiofrequency ablation

Percutaneous ablation using radiofrequency under the imaging guidance

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Inclusion criteria

1. Age between 20 and 70 years 2. Child-Pugh class A (score 5-6) 3. Single hepatocellular carcinoma 4. Maximal diameter of the tumor from 2 to 4 cm when measured on MRI or CT (The diameter on MRI was measured prior to that on CT) 5. No previous treatment 6. Platelet count \> 80,000/mm3

Exclusion criteria

1. HCC abutting main hepatic veins or the first branches of the main portal vein 2. HCC abutting vessels ≥ 0.5 cm

Design outcomes

Primary

Measure	Time frame
The patient survival	From the intervention up to 5 years or until the death of the participant whichever came first

Secondary

Measure	Time frame
The disease-free survival	From the intervention up to 5 years or until hepatocellular carcinoma recurrence whichever came first

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026